Cbz-L-谷氨酸 1-苄酯合成路线 （共 27 条）
反应条件
1: 75 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran 2: 76 percent / H2, AcOH / Pd / methanol / 24 h 3: 4.1 percent / Et3N / dimethylformamide; H2O / 20 h / 40 °C View Scheme
参考文献
Fujii; Sakurai; Akaji; Nomizu; Yajima; Mizuta; Aono; Moriga; Inoue; Hosotani
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2397 - 2410
反应条件
1: H2SO4 2: (hydrogenation) View Scheme
参考文献
Schroeder,E.; Klieger,E.
Justus Liebigs Annalen der Chemie, 1964 , vol. 673, p. 196 - 207
反应条件
1: tributylamine; chlorocarbonic acid ethyl ester; dioxane / anschliessend Behandeln mit L-Alanin-benzylester-hydrochlorid und Tributylamin in Dioxan 2: palladium; aqueous acetic acid / Hydrogenation View Scheme
参考文献
Sachs; Brand
Journal of the American Chemical Society, 1953 , vol. 75, p. 4608
反应条件
1: 62 percent / Et3N / tetrahydrofuran; dimethylformamide / -5 deg C, 1 h, RT, 4 h 2: 68 percent / H2 / 10percent Pd-C / aq. acetic acid / 4 h View Scheme
参考文献
Sekine; Itakura; Namihisa; Takahashi; Nakayama; Kanaoka
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3286 - 3289
反应条件
1: DCC / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) r.t., 5 h 2: Et3N / dimethylformamide; H2O / 24 h / Ambient temperature 3: 84 percent / H2 / Pd black / aq. acetic acid; methanol / 5 h View Scheme
参考文献
Sachs; Brand
Journal of the American Chemical Society, 1954 , vol. 76, p. 3601
反应条件
1: 85 percent / DCC 2: 72 percent / H2 / Pd black / aq. acetic acid; methanol / 5 h View Scheme
参考文献
Sachs; Brand
Journal of the American Chemical Society, 1953 , vol. 75, p. 4608
反应条件
hydrogen bromide; acetic acid
参考文献
Justus Liebigs Annalen der Chemie, , vol. 655, p. 195 - 210
反应条件
dicyclohexyl-carbodiimide in 1,4-dioxane T=4°C; 12 h;
参考文献
Verbruggen, Christophe; De Craecker, Sofie; Rajan, Padinchare; Jiao, Xian-Yun; Borloo, Marianne; Smith, Keith; Fairlamb, Alan H.; Haemers, Achiel
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 3 p. 253 - 258
反应条件
1: (i) ClCO2Et, Et3N, (ii) /BRN= 4597520/, (iii) aq. KCN, AcOH 2: H2 / Pd / 2-methyl-propan-2-ol View Scheme
参考文献
Chemische Berichte, , vol. 96, p. 2566 - 2576
反应条件
1: Cs2CO3
2: H2 / Pd-C
View Scheme
参考文献
Rosowsky,A. et al.
Journal of Medicinal Chemistry, 1978 , vol. 21, p. 380 - 386
