2,2,2-三氟-1-[3-(羟基甲基)苯基]乙酮合成路线 （共 2 条）
反应条件
hydrogenchloride in methanol
T=10 - 20°C; 0.5 h;
参考文献
Doucet-Personeni; Bentley; Fletcher; Kinkaid; Kryger; Pirard; Taylor; Viner; Silman; Sussman; Greenblatt; Lewis
Journal of Medicinal Chemistry, 2001 , vol. 44, # 20 p. 3203 - 3215
反应条件
1.1: 74.5 g / imidazole / dimethylformamide / 20 h / 50 °C
2.1: n-BuLi / diethyl ether; hexane / 0.5 h / 0 - 10 °C
2.2: 70.0 g / diethyl ether; hexane / 1 h
3.1: 31.7 g / aq. HCl / methanol / 0.5 h / 10 - 20 °C
View Scheme
参考文献
Doucet-Personeni; Bentley; Fletcher; Kinkaid; Kryger; Pirard; Taylor; Viner; Silman; Sussman; Greenblatt; Lewis
Journal of Medicinal Chemistry, 2001 , vol. 44, # 20 p. 3203 - 3215
