二乙基2-[[[3-(三氟甲基)苯基]氨基]亚甲基]丙二酸酯合成路线 （共 11 条）
反应条件
1: diphenyl ether / Heating 2: 2 N NaOH / Heating 3: diphenyl ether / 1 h / Heating 4: POCl3 / 1.17 h / 100 - 110 °C View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
反应条件
1: diphenyl ether / Heating 2: 2 N NaOH / Heating 3: diphenyl ether / 1 h / Heating View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
反应条件
dowtherm T=250°C; 5 h;
参考文献
Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432
反应条件
1: diphenyl ether / Heating 2: 2 N NaOH / Heating View Scheme
参考文献
Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432
反应条件
1: dowtherm / 5 h / 250 °C 2: hydrazine / ethanol / 4 h / |Reflux View Scheme
参考文献
Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
参考文献
3M Innovative Properties Company
Patent: US6110929 A1, 2000 ;
反应条件
1: acetic anhydride; zinc(II) chloride / 4 h / |Inert atmosphere; |Reflux
2: ethanol / 2 h / |Reflux
View Scheme
参考文献
Cui, Sheng-Feng; Ren, Yu; Zhang, Shao-Lin; Peng, Xin-Mei; Damu, Guri L.V.; Geng, Rong-Xia; Zhou, Cheng-He
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3267 - 3272
反应条件
in diphenylether
1 h; Heating / reflux;
参考文献
YUNGJIN PHARMACEUTICAL CO., LTD.
Patent: WO2008/93940 A1, 2008 ;
Location in patent: Page/Page column 60-61 ;
WO 2008/093940 A1
反应条件
in diphenylether
Gould-Jacobs reaction; Reflux;
参考文献
Niedermeier, Sabine; Singethan, Katrin; Rohrer, Sebastian G.; Matz, Magnus; Kossner, Markus; Diederich, Sandra; Maisner, Andrea; Schmitz, Jens; Hiltensperger, Georg; Baumann, Knut; Holzgrabe, Ulrike; Schneider-Schaulies, Jurgen
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4257 - 4265
