(8S)-5,6,7,8-四氢-8-氨基喹啉合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C;
参考文献
Uenishi, Junichi; Hamada, Masahiro
Synthesis, 2002 , # 5 p. 625 - 630
反应条件
1: 43 percent / Candida antartica lipase; 4 Angstroem molecular sieves / diisopropyl ether / 30 h / 60 °C 2: 88 percent / K2CO3 / methanol / 2 h / 20 °C 3: 99 percent / DMAP; MsCl; NaN3 / CH2Cl2; dimethylsulfoxide / 2.5 h / 20 °C 4: 92 percent / H2 / 5 percent Pd/C / ethanol / 20 °C View Scheme
参考文献
Kureha Chemical Industry Co., Ltd.
Patent: EP1389460 A1, 2004 ;
Location in patent: Page/Page column 105 ;
EP 1389460 A1
反应条件
trifluoroacetic acid in anhydrous dichloroethane 4 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/23400 A2, 2006 ;
Location in patent: Page/Page column 167 ;
反应条件
Candida antarctica lipase B in di-isopropyl ether T=60°C; 4 h;
参考文献
Skupinska, Krystyna A.; McEachern, Ernest J.; Baird, Ian R.; Skerlj, Renato T.; Bridger, Gary J.
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3546 - 3551
反应条件
1: 99 percent / DMAP; MsCl; NaN3 / CH2Cl2; dimethylsulfoxide / 2.5 h / 20 °C 2: 92 percent / H2 / 5 percent Pd/C / ethanol / 20 °C View Scheme
参考文献
Uenishi, Junichi; Hamada, Masahiro
Synthesis, 2002 , # 5 p. 625 - 630
反应条件
1: 88 percent / K2CO3 / methanol / 2 h / 20 °C 2: 99 percent / DMAP; MsCl; NaN3 / CH2Cl2; dimethylsulfoxide / 2.5 h / 20 °C 3: 92 percent / H2 / 5 percent Pd/C / ethanol / 20 °C View Scheme
参考文献
Uenishi, Junichi; Hamada, Masahiro
Synthesis, 2002 , # 5 p. 625 - 630
反应条件
sodium tris(acetoxy)borohydride in dichloromethane
参考文献
Crawford, Jason B.; Chen, Gang; Gauthier, David; Wilson, Trevor; Carpenter, Bryon; Baird, Ian R.; McEachern, Ernie; Kaller, Alan; Harwig, Curtis; Atsma, Bem; Skerlj, Renato T.; Bridger, Gary J.
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 823 - 830
