2-甲基-2-丙基[5-(氨基甲基)-2-吡嗪基]氨基甲酸酯合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
P=760 Torr;
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
反应条件
1.1: DPPA; Et3N / dioxane / 100 °C
1.2: 70 percent / 25 h
2.1: 54 percent / NBS; (PhCO2)2; NaHCO3 / CCl4 / Heating
3.1: 98 percent / NaN3 / dimethylformamide / 5 h / 20 °C
4.1: 98 percent / H2 / Pd/C / methanol / 760 Torr
View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
反应条件
1: 54 percent / NBS; (PhCO2)2; NaHCO3 / CCl4 / Heating
2: 98 percent / NaN3 / dimethylformamide / 5 h / 20 °C
3: 98 percent / H2 / Pd/C / methanol / 760 Torr
View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
反应条件
1: 98 percent / NaN3 / dimethylformamide / 5 h / 20 °C
2: 98 percent / H2 / Pd/C / methanol / 760 Torr
View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
