aluminum oxide T=20°C; 0.0833333 h;

hydrotalcite; Ti(4+) montmorillonite in toluene T=80°C; 1 h;

sodium in methanol T=0 - 20°C; 5 h;

hydrogenchloride in water 24 h; Reflux;

1: water 2: MgAl-layered doubled oxides at Al-containing mesoporous silica / toluene / 2 h / 110 °C View Scheme

hydrogenchloride

2: HCl View Scheme

methanol

1: 98 percent / NaBH4 / propan-2-ol / 20 °C 2: 47 percent / triphenylphosphine; diisopropyl azodicarboxylate; hydrazoic acid / tetrahydrofuran; toluene / 0.02 h / cooling 3: 49 percent / Rhodococcus erythropolis AJ270; potassium phosphate buffer / H2O / 3.5 h / pH 7.0 4: 93 percent / hydrogen / Pd/C / methanol / 3 h View Scheme

1: 98 percent / NaBH4 / propan-2-ol / 20 °C 2: 47 percent / triphenylphosphine; diisopropyl azodicarboxylate; hydrazoic acid / tetrahydrofuran; toluene / 0.02 h / cooling 3: 48 percent / Rhodococcus erythropolis AJ270; potassium phosphate buffer / H2O / 3.5 h / pH 7.0 4: 96 percent / HCl / H2O / 43 h / 55 °C 5: 93 percent / hydrogen / Pd/C / methanol / 3 h View Scheme