2-氮杂双环[2,2,2]辛-5-烯-2-羧酸乙酯合成路线 （共 2 条）
反应条件
boron trifluoride diethyl etherate in benzene
1 h; Reflux;
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SAMES, Dalibor; LI, Xiaoguang; LI, Shu; KRUEGEL, Andrew; KARPOWICZ, Richard; CARRERA, Ignacio; RAKSHIT, Souvik
Patent: WO2013/28999 A1, 2013 ;
Location in patent: Page/Page column 76; 77 ;
反应条件
1.1: Hg(AcO)2 / tetrahydrofuran; H2O / 24 h / 20 °C
1.2: NaBH4; 3 M NaOH
2.1: Et3N / CH2Cl2 / 1.5 h / 0 - 20 °C
3.1: NaN3 / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
4.1: LiAlH4 / tetrahydrofuran / 5 h / Heating
View Scheme
参考文献
Iriepa, Isabel; Villasante, Francisco J.; Galvez, Enrique; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 189 - 192
