1,4-双(二氟甲基)苯合成路线 （共 20 条）
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane Fluorination; 16 h; Heating;
参考文献
Lal, Gauri S.; Pez, Guido P.; Pesaresi, Reno J.; Prozonic, Frank M.; Cheng, Hansong
Journal of Organic Chemistry, 1999 , vol. 64, # 19 p. 7048 - 7054
反应条件
cesium fluoride T=180°C; 8 h;
参考文献
Dolbier Jr., William R.; Duan, Jian-Xin; Rong, Xiao X.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1091 - 1093
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride; tetra-phenylphosphonium bromide T=170 - 190°C; 5 - 26 h; Neat (no solvent); Product distribution / selectivity;
参考文献
Yuan-Shin Materials Technology Corp.
Patent: US2006/211894 A1, 2006 ;
Location in patent: Page/Page column 3; 4 ;
反应条件
1: With 2-Fluoro-1-methylpyridinium 4-methylbenzenesulphonate; TBAF*HF; triethylamine T=80°C; 6 h; 2: With water 3: With sodium hydrogencarbonate in water
参考文献
Rhodia Chimie; CNRS
Patent: US2009/234151 A1, 2009 ;
Location in patent: Page/Page column 11-12 ;
反应条件
pyridine hydrogenfluoride; 1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=0°C; 2 h; Argon, moisture content not more 1 volppmHF-Pyridine is about 40 times thant of the intermediate 1Intermediate 1 was introduceed into several portions;
参考文献
Nippon Shokubai Co., Ltd.
Patent: US6384289 B1, 2002 ;
Location in patent: Page column 8 ;
反应条件
potassium fluoride T=300°C; 24 h; Neat (no solvent);
参考文献
Jong, Shean Jeng; Hsu, Hong Yu
Patent: US2005/283031 A1, 2005 ;
Location in patent: Page/Page column 3 ;
反应条件
SbF3 T=120°C; P=40 Torr;
参考文献
Grechkina, E. V.; Sochilin, V. A.; Pebalk, A. V.; Kardash, I. E.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 10 p. 1663 - 1665
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 10 p. 1999 - 2001
反应条件
potassium fluoride T=350°C; 12 h; Neat (no solvent);
参考文献
Yuan-Shin Materials Technology Corp.
Patent: US2006/211894 A1, 2006 ;
Location in patent: Page/Page column 3; 4 ;
反应条件
potassium fluoride T=400°C; 4 h; Neat (no solvent);
参考文献
Yuan-Shin Materials Technology Corp.
Patent: US2006/211894 A1, 2006 ;
Location in patent: Page/Page column 2; 3 ;
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride T=190°C; 44 h; Neat (no solvent); Product distribution / selectivity;
参考文献
Yuan-Shin Materials Technology Corp.
Patent: US2006/211894 A1, 2006 ;
Location in patent: Page/Page column 2; 3 ;
