3-氟-4-甲氧基苯甲酸甲酯合成路线 （共 6 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 371 ;
反应条件
formic acid; fluorine T=10°C; Fluorination; 1.75 h;
参考文献
Chambers, Richard D.; Hutchinson, John; Sparrowhawk, Matthew E.; Sandford, Graham; Moilliet, John S.; Thomson, Julie
Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 169 - 173
反应条件
1: 69 percent / AlCl3, LiAlH4 / diethyl ether / 1.) R.T. 1 h, 2.) reflux 1 h. 2: 54 percent / SOCl2 / 1.) R.T. 2 d, 2.) 90 deg C, 1 h. View Scheme
参考文献
Cervena, Irena; Holubek, Jiri; Svatek, Emil; Valchar, Martin; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 10 p. 2564 - 2571
反应条件
1: With potassium hydroxide; water in methanol 1 h; Heating / reflux; 2: With hydrogenchloride in water pH=2;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 371 ;
反应条件
lithium aluminium tetrahydride; aluminium trichloride in diethyl ether 1.) R.T. 1 h, 2.) reflux 1 h.;
参考文献
Cervena, Irena; Holubek, Jiri; Svatek, Emil; Valchar, Martin; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 10 p. 2564 - 2571
反应条件
1: nitric acid / 0 °C 2: platinum; methanol / Hydrogenation View Scheme
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
