2,4-二甲氧基-6-甲基苯甲酸合成路线 （共 39 条）
反应条件
1: K2CO3 / acetone / Heating
2: 99 percent / KOH / ethanol
View Scheme
参考文献
Chevenier, Emmanuel; Lucatelli, Christophe; Pandya, Urvish; Wang, Wei; Gimbert, Yves; Greene, Andrew E.
Synlett, 2004 , # 15 p. 2693 - 2696
反应条件
1: acetonitrile
2: NaNH2 / liquid ammonia
3: aq. KMnO4, NaOH
View Scheme
参考文献
Beard,W.Q. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2310 - 2316
反应条件
1: NaNH2 / liquid ammonia
2: aq. KMnO4, NaOH
View Scheme
参考文献
Beard,W.Q. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2310 - 2316
反应条件
1: 78 percent / hydrazine hydrate / 2 h / Heating
2: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C
3: 93 percent / toluene / 2.5 h / Heating
4: 8.7 g / sodium hydroxide (20percent) / 60 °C
8: 28.8 g / fluoroboric acid, sodium nitrite / H2O
9: 7.6 g / warming, distillation
10: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 84 percent / sodium hydroxide / heating
5: 28.8 g / fluoroboric acid, sodium nitrite / H2O
6: 7.6 g / warming, distillation
7: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
2: 28.8 g / fluoroboric acid, sodium nitrite / H2O
3: 7.6 g / warming, distillation
4: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 93 percent / toluene / 2.5 h / Heating
2: 8.7 g / sodium hydroxide (20percent) / 60 °C
6: 28.8 g / fluoroboric acid, sodium nitrite / H2O
7: 7.6 g / warming, distillation
8: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C
2: 93 percent / toluene / 2.5 h / Heating
3: 8.7 g / sodium hydroxide (20percent) / 60 °C
7: 28.8 g / fluoroboric acid, sodium nitrite / H2O
8: 7.6 g / warming, distillation
9: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
4: 28.8 g / fluoroboric acid, sodium nitrite / H2O
5: 7.6 g / warming, distillation
6: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
3: 28.8 g / fluoroboric acid, sodium nitrite / H2O
4: 7.6 g / warming, distillation
5: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
