4-(氨基乙基)-2-氟苯腈合成路线 (共 6 条)
反应条件
thiophenol; triethylamine; tin(ll) chloride in acetonitrile 1.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2003/101956 A1, 2003 ;
Location in patent: Page 128; 129 ;
WO 03/101956 A1
反应条件
hydrazine in butan-1-ol 0.0833333 h; Heating;
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
1: 94 percent / dimethylformamide / 5 h / Heating 2: 54 percent / NBS; AIBN / CCl4 / 4.5 h / Heating 3: 91 percent / Cs2CO3 / dimethylformamide / 0.5 h / 20 °C 4: NH2NH2 / butan-1-ol / 0.08 h / Heating View Scheme
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
1: 54 percent / NBS; AIBN / CCl4 / 4.5 h / Heating 2: 91 percent / Cs2CO3 / dimethylformamide / 0.5 h / 20 °C 3: NH2NH2 / butan-1-ol / 0.08 h / Heating View Scheme
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
1: 91 percent / Cs2CO3 / dimethylformamide / 0.5 h / 20 °C 2: NH2NH2 / butan-1-ol / 0.08 h / Heating View Scheme
参考文献
Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; Ho, Jonathan Z.; Siev, Daniel V.; Mamedova, Lala; Gibson, Tony S.; Gaudette, John A.; Minami, Nathaniel K.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2925 - 2930
反应条件
in dichloromethane T=20°C; 1 h;
参考文献
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; STRONGIN, Alex; PELLECCHIA, Maurizio; BARILE, Elisa
Patent: WO2013/138665 A1, 2013 ;
Location in patent: Paragraph 00092 ;