benzenesulfonamide; O,O,O',O'-tetramethyl O,O'-thiodi-p-phenylene phosphorothioate; potassium acetate; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran T=20°C; 12 h;

1: N-(prop-2-ynyl)-4-methyl benzenesulfonamide With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h; Inert atmosphere; 2: cyclopent-2-enyl bromide in N,N-dimethyl-formamide T=20°C; 0.333333 h; Inert atmosphere;

1.1: triethylamine / dichloromethane / 1 h 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / |Inert atmosphere 2.2: 0.33 h / 20 °C / |Inert atmosphere View Scheme