2-氧代-4-甲基戊酸甲酯合成路线 （共 14 条）
反应条件
chloro-trimethyl-silane in 2,2-dimethoxy-propane T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/140183 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
chloro-trimethyl-silane T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 19-20 ;
反应条件
hydrogenchloride in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
hydrogenchloride in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
hydrogenchloride in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
1: 79 percent / triethylamine / 1 h / Ambient temperature 2: 95 percent / 1 M HCl / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
1: 94 percent / thionyl chloride, acetyl chloride / 4 h / Ambient temperature 2: 79 percent / triethylamine / 1 h / Ambient temperature 3: 95 percent / 1 M HCl / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Shin; Yonezawa; Yamada
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3934 - 3944
反应条件
sulfuric acid in tetrahydrofuran; diethyl ether Heating;
参考文献
Poisel,H.
Chemische Berichte, 1978 , vol. 111, p. 3136 - 3139
反应条件
1: (i) tBuOCl, (ii) /BRN= 3592982/ 2: aq. H2SO4 / diethyl ether; tetrahydrofuran / Heating View Scheme
参考文献
Poisel,H.
Chemische Berichte, 1978 , vol. 111, p. 3136 - 3139
反应条件
hydrogenchloride Heating;
参考文献
Iwakura,Y. et al.
Journal of Organic Chemistry, 1966 , vol. 31, p. 2875 - 2878
