1-[3,5-双(三氟甲基)苯基]乙醇合成路线 （共 20 条）
反应条件
sodium hydroxide; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in isopropyl alcohol
参考文献
Brands, Karel M. Jos; Payack, Joseph F.; Pye, Philip J.
Patent: US2002/52493 A1, 2002 ;
反应条件
C51H57ClFeN2OP2(1+)*BF4(1-); potassium tert-butylate; isopropyl alcohol T=28°C; 0.00277778 h; Catalytic behavior; Reagent/catalyst; enantioselective reaction;
参考文献
Zuo, Weiwei; Lough, Alan J.; Li, Young Feng; Morris, Robert H.
Science, 2013 , vol. 342, # 6162 p. 1080 - 1083
反应条件
sodium hydroxide in isopropyl alcohol
参考文献
Brands, Karel M. Jos; Payack, Joseph F.; Pye, Philip J.
Patent: US2002/52493 A1, 2002 ;
反应条件
dimethylsulfide borane complex; chiral oxazaborolidine in dichloromethane; toluene T=-20°C; Title compound not separated from byproducts;
参考文献
Reichard, Gregory A.; Stengone, Carmine; Paliwal, Sunil; Mergelsberg, Ingrid; Majmundar, Sapna; Wang, Cheng; Tiberi, Robert; McPhail, Andrew T.; Piwinski, John J.; Shih, Neng-Yang
Organic Letters, 2003 , vol. 5, # 23 p. 4249 - 4251
反应条件
hydrogenchloride in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
Huskey, Su-er Wu; Chiu, Shuet-Hing Lee
Patent: US2004/23960 A1, 2004 ;
US 20040023960 A1
反应条件
polyoxyethylene (10) cetyl ether; n-octyl beta-D-glucopyranoside; subtilisin Carlsberg; sodium carbonate in tetrahydrofuran T=20°C; 16 h; Title compound not separated from byproducts;
参考文献
Boren, Linnea; Martin-Matute, Belen; Xu, Yongmei; Cordova, Armando; Baeckvall, Jan-E.
Chemistry - A European Journal, 2006 , vol. 12, # 1 p. 225 - 232
反应条件
3 A molecular sieve; oxygen; (-)-sparteine; Pd((-)-sparteine)2Cl2 in tert-butyl alcohol T=65°C; 20 h; Title compound not separated from byproducts;
参考文献
Mandal, Sunil K.; Jensen, David R.; Pugsley, Jacob S.; Sigman, Matthew S.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4600 - 4603
反应条件
Candida antartica lipase B in various solvent(s) T=40°C; P=67505.4 Torr; 2 h;
参考文献
Matsuda, Tomoko; Tsuji, Kazuhiko; Kamitanaka, Takashi; Harada, Tadao; Nakamura, Kaoru; Ikariya, Takao
Chemistry Letters, 2005 , vol. 34, # 8 p. 1102 - 1103
反应条件
1.1: Mg / tetrahydrofuran / 0 - 20 °C 1.2: 89 percent / tetrahydrofuran / -78 - 20 °C 2.1: 82 percent / aq. NaOH; aq. H2O2 / diethyl ether / 16 h View Scheme
参考文献
Singh; Twamley; Fabry-Asztalos; Matteson; Shreeve
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 8123 - 8125
反应条件
hydrogenchloride in methanol Heating;
参考文献
Vankawala, Pravinchandra J.; Kolla, Naveenkumar; Elati, Chandrashekar R.; Sreenivasulu; Kumar, K. Arun; Anjaneyulu, Yerrimilli; Venkatraman, Sundaram; Bhattacharya, Apurba; Mathad, Vijayavitthal T.
Synthetic Communications, 2007 , vol. 37, # 19 p. 3439 - 3446
