4-羟基-6-(三氟甲基)嘧啶-2-硫醇合成路线 （共 17 条）
反应条件
sodium hydride in acetonitrile; mineral oil Reflux;
参考文献
Khudina; Ivanova; Burgart; Slepukhin; Saloutin; Chupakhin; Kravchenko
Russian Chemical Bulletin, 2013 , vol. 62, # 4 p. 1060 - 1065
Izvestiya Akademii Nauk. Seriya Khimicheskaya, 2013 , # 4 p. 1059 - 1064,6
反应条件
1: 87 percent / NaOH / H2O / 1) RT, 3 h; 2) reflux, 5 min 2: 70 percent / POCl3 / dimethylaniline 3: 60 percent / NH3 / methanol / 1) 0 deg C, 0.5 h; 2) -15 deg C, 4 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 87 percent / NaOH / H2O / 1) RT, 3 h; 2) reflux, 5 min 2: 79 percent / 10 percent HCl / 8 h / Heating 3: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight 4: 47 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
2: aqueous HCl View Scheme
参考文献
Giner-Sorolla; Bendich
Journal of the American Chemical Society, 1958 , vol. 80, p. 5744,5751
反应条件
1: Raney nickel; aqueous NH3 2: POCl3; N,N-diethyl-aniline / anschliessendes Behandeln mit aethanol.NH3 View Scheme
参考文献
Giner-Sorolla; Bendich
Journal of the American Chemical Society, 1958 , vol. 80, p. 5744,5751
反应条件
dihydrogen peroxide in tetrahydrofuran; water T=80°C; 2 h;
参考文献
Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2004 , # 17 p. 3714 - 3718
反应条件
1: 87 percent / NaOH / H2O / 1) RT, 3 h; 2) reflux, 5 min 2: 79 percent / 10 percent HCl / 8 h / Heating 3: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight 4: 20 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
sodium hydroxide in water 1) RT, 3 h; 2) reflux, 5 min;
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
in tetrahydrofuran T=25°C; 3 h;
参考文献
Ringom, Rune; Axen, Eva; Uppenberg, Jonas; Lundbaeck, Thomas; Rondahl, Lena; Barf, Tjeerd
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4449 - 4452
反应条件
1: 87 percent / NaOH / H2O / 1) RT, 3 h; 2) reflux, 5 min 2: 70 percent / POCl3 / dimethylaniline View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
