(S)-乙基2-(((s)-2-氧代-2,3,4,5-四氢-1H-苯并[b]氮杂革-3-基)氨基)-4-苯基丁酸酯合成路线 （共 10 条）
反应条件
1.1: tetrabutylammonium bromide; KOH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 98 percent / tetrahydrofuran / 5 h / 20 °C 2.1: 90 percent / HCl / toluene / 1.5 h / 0 - 20 °C View Scheme
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
反应条件
potassium carbonate in water; ethyl acetate
参考文献
ScinoPharm Taiwan, Ltd.
Patent: US2003/55245 A1, 2003 ;
反应条件
1.1: 65 percent / sulfuric acid / toluene / 36 h / Heating
2.1: 100 percent / Et3N / ethanol / 12 h / 20 °C
3.1: H2; HCl / Pd-C / tetrahydrofuran / 40 h / 40 °C / 7757.22 Torr
3.2: acetic acid / toluene / 24 h / Heating
View Scheme
参考文献
Yu, Luo-Ting; Huang, Ji-Ling; Chang, Ching-Yao; Yang, Teng-Kuei
Molecules, 2006 , vol. 11, # 8 p. 641 - 648
反应条件
in ethylene glycol dimethyl ether
T=50°C; 60 h;
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
反应条件
1.1: phenacyl chloride; baker's yeast / diethyl ether; H2O / 24 h / 30 °C
2.1: H2; HCl / Pd/C / methanol / 20 °C
2.2: 42 percent / AcOH / toluene / 80 °C
3.1: Et3N / tetrahydrofuran / 16 h / 20 °C
4.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
View Scheme
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
反应条件
1.1: H2; HCl / Pd/C / methanol / 20 °C
1.2: 42 percent / AcOH / toluene / 80 °C
2.1: Et3N / tetrahydrofuran / 16 h / 20 °C
3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
View Scheme
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
反应条件
1.1: 100 percent / Et3N / ethanol / 12 h / 20 °C
2.1: H2; HCl / Pd-C / tetrahydrofuran / 40 h / 40 °C / 7757.22 Torr
2.2: acetic acid / toluene / 24 h / Heating
View Scheme
参考文献
Yu, Luo-Ting; Huang, Ji-Ling; Chang, Ching-Yao; Yang, Teng-Kuei
Molecules, 2006 , vol. 11, # 8 p. 641 - 648
反应条件
1.1: 100 percent / Et3N / ethanol / 12 h / 20 °C
2.1: H2; HCl / Pd-C / tetrahydrofuran / 40 h / 40 °C / 7757.22 Torr
2.2: acetic acid / toluene / 24 h / Heating
View Scheme
参考文献
Yu, Luo-Ting; Huang, Ji-Ling; Chang, Ching-Yao; Yang, Teng-Kuei
Molecules, 2006 , vol. 11, # 8 p. 641 - 648
反应条件
1.1: H2 / Pd/C / methanol / 24 h / 20 °C
1.2: H2; hydrochloric acid / Pd/C / methanol / 36 h / 20 °C
1.3: 74 percent / AcOH / toluene / 16 h / 80 °C
2.1: Et3N / tetrahydrofuran / 16 h / 20 °C
3.1: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
View Scheme
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
反应条件
1: Et3N / tetrahydrofuran / 16 h / 20 °C
2: 78 percent / 1,2-dimethoxy-ethane / 60 h / 50 °C
View Scheme
参考文献
Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245
