4-氨基-2,2,6,6-四甲基哌啶合成路线 （共 35 条）
反应条件
1: 80 percent / ethanol / 1.5 h / Heating
2: 88 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating
3: 34 percent / Et3N / ethyl acetate / 48 h / 25 °C
View Scheme
参考文献
Tsui; Robey; Engle; Ludeman; Zon
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1106 - 1110
反应条件
sodium hydroxide in water; 1,2-dichloro-ethane
参考文献
Ciba Specialty Chemicals Corporation
Patent: US5847132 A1, 1998 ;
反应条件
in Petroleum ether
1.) 0.5 h, 0 - 5 deg C, 2.) 2 h, room temperature;
参考文献
Baracu, Ileana; Dobre, V.; Niculescu-Duvaz, I.
Journal fuer Praktische Chemie (Leipzig), 1985 , vol. 327, # 4 p. 667 - 674
反应条件
sodium hydroxide
T=20°C; 24 h;
参考文献
Mezzina, Elisabetta; Fani, Michela; Ferroni, Fiammetta; Franchi, Paola; Menna, Manuel; Lucarini, Marco
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3773 - 3777
反应条件
pyridine in tetrahydrofuran
3 h; Ambient temperature;
参考文献
Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313
