4,4-二(苯基)丁烷-1-胺合成路线 （共 9 条）
反应条件
palladium 10 on activated carbon
T=20°C; 8 h;
参考文献
Kowalczyk, Paula; Salat, Kinga; Hoefner, Georg C.; Guzior, Natalia; Filipek, Barbara; Wanner, Klaus T.; Kulig, Katarzyna
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5154 - 5167
反应条件
borane-THF
Inert atmosphere;
参考文献
Shah, Jitesh R.; Mosier, Philip D.; Roth, Bryan L.; Kellogg, Glen E.; Westkaemper, Richard B.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6496 - 6504
反应条件
ammonium chloride; potassium carbonate in 1,4-dioxane; bis-maleimidodiphenyl-methane acid; ammonia; water
参考文献
Warner-Lambert Company
Patent: US4657897 A1, 1987 ;
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethanol; water
P=2280 Torr; 1.5 h;
参考文献
Clausen, Rasmus P.; Moltzen, Ejner K.; Perregaard, Jens; Lenz, Sibylle M.; Sanchez, Connie; Falch, Erik; Frolund, Bente; Bolvig, Tina; Sarup, Alan; Larsson, Orla M.; Schousboe, Arne; Krogsgaard-Larsen, Povl
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 895 - 908
反应条件
1.1: magnesium / tetrahydrofuran / Heating
1.2: tetrahydrofuran
2.1: acetic acid; HI; phosphorus / H2O / 6 h / Heating
3.1: 14 g / sodium azide / dimethylformamide / 1.5 h / Heating
4.1: acetic acid; hydrogen / Pd/C / ethanol; H2O / 1.5 h / 2280 Torr
View Scheme
参考文献
Clausen, Rasmus P.; Moltzen, Ejner K.; Perregaard, Jens; Lenz, Sibylle M.; Sanchez, Connie; Falch, Erik; Frolund, Bente; Bolvig, Tina; Sarup, Alan; Larsson, Orla M.; Schousboe, Arne; Krogsgaard-Larsen, Povl
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 895 - 908
反应条件
1: acetic acid; HI; phosphorus / H2O / 6 h / Heating
2: 14 g / sodium azide / dimethylformamide / 1.5 h / Heating
3: acetic acid; hydrogen / Pd/C / ethanol; H2O / 1.5 h / 2280 Torr
View Scheme
参考文献
Clausen, Rasmus P.; Moltzen, Ejner K.; Perregaard, Jens; Lenz, Sibylle M.; Sanchez, Connie; Falch, Erik; Frolund, Bente; Bolvig, Tina; Sarup, Alan; Larsson, Orla M.; Schousboe, Arne; Krogsgaard-Larsen, Povl
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 895 - 908
反应条件
1: 14 g / sodium azide / dimethylformamide / 1.5 h / Heating
2: acetic acid; hydrogen / Pd/C / ethanol; H2O / 1.5 h / 2280 Torr
View Scheme
参考文献
Clausen, Rasmus P.; Moltzen, Ejner K.; Perregaard, Jens; Lenz, Sibylle M.; Sanchez, Connie; Falch, Erik; Frolund, Bente; Bolvig, Tina; Sarup, Alan; Larsson, Orla M.; Schousboe, Arne; Krogsgaard-Larsen, Povl
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 895 - 908
反应条件
1.1: potassium phtalimide; 18-crown-6 ether / toluene / 20 h / |Reflux
1.2: 3 h / |Reflux
2.1: palladium 10 on activated carbon / 8 h / 20 °C
View Scheme
参考文献
Kowalczyk, Paula; Salat, Kinga; Hoefner, Georg C.; Guzior, Natalia; Filipek, Barbara; Wanner, Klaus T.; Kulig, Katarzyna
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5154 - 5167
反应条件
triethylamine in dichloromethane
T=10°C; 4.08333 h;
参考文献
IONIX PHARMACEUTICALS LIMITED
Patent: WO2005/5392 A1, 2005 ;
Location in patent: Page 50 ;
WO 2005/005392 A1
