反式,反式-法尼基酸甲酯合成路线 （共 42 条）
反应条件
1: 1.68 g / lithium aluminium hydride / diethyl ether / 2 h / Heating 2: phosphorus tribromide 3: sodium / ethanol 4: 288 mg 5: lithium aluminium hydride View Scheme
参考文献
Trost,B.M. et al.
Journal of the American Chemical Society, 1978 , vol. 100, p. 3426 - 3435
反应条件
1: 1.68 g / lithium aluminium hydride / diethyl ether / 2 h / Heating 2: phosphorus tribromide View Scheme
参考文献
Suga, Takayuki; Shishibori, Tsuyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2098 - 2104
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Burrell,J.W.K. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 2144 - 2154
反应条件
1: 1.68 g / lithium aluminium hydride / diethyl ether / 2 h / Heating 2: phosphorus tribromide 3: sodium / ethanol View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2098 - 2104
反应条件
1: methyllithium With copper(l) iodide in diethyl ether
T=0°C; 0.0833333 h; Inert atmosphere;
2: (2Z,6E)-3-(Diethoxy-phosphoryloxy)-7,11-dimethyl-dodeca-2,6,10-trienoic acid methyl ester in diethyl ether
T=-78 - -30°C; 2 h; Inert atmosphere;
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SNYDER, Scott, Alan; TREITLER, Daniel, S.; BRUCKS, Alexandria, P.; GOLLNER, Andreas; CHIRIAC, Maria, I.; WRIGHT, Nathan, E.; PFLUEGER, Jason, J.; BREAZZANO, Steven, P.
Patent: WO2012/37069 A2, 2012 ;
Location in patent: Page/Page column 116 ;
反应条件
potassium cyanide; manganese(IV) oxide; acetic acid
T=20°C; 24 h;
参考文献
Stritzke, Katja; Schulz, Stefan; Boppre, Michael
European Journal of Organic Chemistry, 2003 , # 7 p. 1337 - 1342
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; Wittig reaction; 18 h;
参考文献
Andersen, John F.; Walding, Jennifer K.; Evans, Philip H.; Bowers, William S.; Feyereisen, Rene
Chemical Research in Toxicology, 1997 , vol. 10, # 2 p. 156 - 164
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
2 h;
参考文献
Kim, Sanghee; Kim, Eunkyung; Shin, Dong-Sun; Kang, Heonjoong; Oh, Ki-Bong
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 6 p. 895 - 898
参考文献
Anderson; Henrick; Siddall; Zurflueh
Journal of the American Chemical Society, 1972 , vol. 94, # 15 p. 5379 - 5386
反应条件
1: 77 percent / NaClO2; aq. NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 2 h
2: 76 percent / EDCI / CH2Cl2 / 6 h
3: 73 percent / EDCI; DMAP / CH2Cl2 / 2 h
View Scheme
参考文献
Kim, Sanghee; Kim, Eunkyung; Shin, Dong-Sun; Kang, Heonjoong; Oh, Ki-Bong
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 6 p. 895 - 898
