BOC-L-苯丙氨酸琥珀酰亚胺酯合成路线 （共 19 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane a.) -5 deg C, 2h, b.) 4 deg C, 40h;
参考文献
Lyubeznova, M. R.; Karpeiskaya, E. I.; Klabunovskii, E. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 4.1 p. 720 - 726
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 4 p. 811 - 818
反应条件
4-(N,N-dimethlyamino)pyridine in 1,4-dioxane T=20°C; 19 h;
参考文献
Howard, Nigel I.; Bugg, Timothy D. H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 14 p. 3083 - 3099
反应条件
potassium carbonate in tetrahydrofuran; ethyl acetate; citric acid
反应条件
pyridine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
反应条件
1: aq. NaHCO3 / tetrahydrofuran / 12 h / 23 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dioxane / 2 h / 23 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 7, # 19 p. 4280 - 4295
反应条件
1: aq. NaHCO3 / tetrahydrofuran / 12 h / 23 °C 2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dioxane / 2 h / 23 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 7, # 19 p. 4280 - 4295
反应条件
pyridine in acetonitrile
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5559 - 5562
反应条件
hydrogenchloride; sodium hydrogencarbonate; triethylamine in tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate
参考文献
Ajinomoto Co., Inc.
Patent: US4257939 A1, 1981 ;
反应条件
sodium tetrahydroborate; acetic acid in 1,4-dioxane; methanol
参考文献
Sergeev, Maxim E.; Pronin, Victor B.; Voyushina, Tatiana L.
Synlett, 2005 , # 18 art. no. G24405ST, p. 2802 - 2804
