3-(4-甲氧基苯基)-5-苯基-1,2-恶唑合成路线 （共 52 条）
反应条件
potassium hydrogencarbonate; copper(II) sulfate; sodium L-ascorbate in tert-butyl alcohol
T=20°C; 1 h;
参考文献
Himo, Fahmi; Lovell, Timothy; Hilgraf, Robert; Rostovtsev, Vsevolod V.; Noodleman, Louis; Sharpless, K. Barry; Fokin, Valery V.
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 210 - 216
反应条件
bis-[(trifluoroacetoxy)iodo]benzene in methanol; water
T=20°C; 7 h; regioselective reaction;
参考文献
Jawalekar, Anup M.; Reubsaet, Erik; Rutjes, Floris P. J. T.; Van Delft, Floris L.
Chemical Communications, 2011 , vol. 47, # 11 p. 3198 - 3200
反应条件
sodium hydrogencarbonate in water; isopropyl alcohol
T=20°C; 3 h; regioselective reaction;
参考文献
Soltani Rad; Behrouz; Faghihi
Journal of the Iranian Chemical Society, 2014 , vol. 11, # 2 p. 361 - 367
反应条件
1: With TsNHOH; potassium carbonate in methanol; water
T=40°C; 24 h;
2: With potassium carbonate in methanol; water
T=60°C; 10 h; regiospecific reaction;
参考文献
Tang, Shibing; He, Jinmei; Sun, Yongquan; He, Liuer; She, Xuegong
Organic Letters, 2009 , vol. 11, # 17 p. 3982 - 3985
反应条件
bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; hydroxylamine in N,N-dimethyl-formamide
T=20°C; Sonogashira coupling;
参考文献
Mohamed Ahmed, Mohamed S.; Kobayashi, Kei; Mori, Atsunori
Organic Letters, 2005 , vol. 7, # 20 p. 4487 - 4489
反应条件
1: N-chlorosuccinimide / dimethylformamide / 1 h / 20 °C
2: 92 percent / aq. sodium ascorbate; copper(II) sulfate pentahydrate; KHCO3 / 2-methyl-propan-2-ol / 1 h / 20 °C
View Scheme
参考文献
Himo, Fahmi; Lovell, Timothy; Hilgraf, Robert; Rostovtsev, Vsevolod V.; Noodleman, Louis; Sharpless, K. Barry; Fokin, Valery V.
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 210 - 216
反应条件
1: aq. NaOH; hydroxylamine hydrochloride / ethanol / 1 h / 20 °C
2: N-chlorosuccinimide / dimethylformamide / 1 h / 20 °C
3: 92 percent / aq. sodium ascorbate; copper(II) sulfate pentahydrate; KHCO3 / 2-methyl-propan-2-ol / 1 h / 20 °C
View Scheme
参考文献
Himo, Fahmi; Lovell, Timothy; Hilgraf, Robert; Rostovtsev, Vsevolod V.; Noodleman, Louis; Sharpless, K. Barry; Fokin, Valery V.
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 210 - 216
反应条件
hydroxylamine hydrochloride; sodium acetate in ethanol; water; acetic acid; benzene
pH=2.2; Reflux; regioselective reaction;
参考文献
Raghava, Byregowda; Parameshwarappa, Gangajji; Acharya, Anand; Swaroop, Toreshettahally R.; Rangappa, Kanchugarakoppal S.; Ila, Hiriyakkanavar
European Journal of Organic Chemistry, 2014 , vol. 2014, # 9 p. 1882 - 1892
反应条件
potassium hydroxide in 1,4-dioxane
T=101°C; 4 h;
参考文献
Balasundaram, B.; Perumal, P.T.
Synthetic Communications, 1990 , vol. 20, # 20 p. 3161 - 3166
反应条件
in diethyl ether
T=0 - 10°C;
参考文献
Baranski, Andrzej
Polish Journal of Chemistry, 1986 , vol. 60, # 4-6 p. 419 - 427
