5-(4-甲氧基苯基)-3-苯基-1,2-恶唑合成路线 （共 43 条）
反应条件
1: potassium phosphate / dichloromethane / 18 h / 20 °C
2: chloro(2-dicyclohexylphosphino-2',4',6'-triisoporpyl-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)] palladium (II); copper (II) acetate monohydrate; potassium carbonate / isopropyl alcohol; acetonitrile / 0.33 h / 120 °C / Microwave irradiation
View Scheme
参考文献
Grob, Jonathan E.; Nunez, Jill; Dechantsreiter, Michael A.; Hamann, Lawrence G.
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10241 - 10248
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / 0 - 20 °C
1.2: 2 h / 0 - 20 °C
1.3: 2 h / |Reflux
2.1: tetra-(n-butyl)ammonium iodide; hydroxylamine hydrochloride / water / 5 h / |Inert atmosphere; |Reflux
3.1: toluene-4-sulfonic acid / water / 1 h / 20 °C
View Scheme
参考文献
Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2049 - 2058
反应条件
tetrahydrofuran; n-butyllithium
参考文献
Beam,C.F. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 1806 - 1810
参考文献
Battaglia,A. et al.
Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 721 - 724
反应条件
sodium hydroxide; hydroxylamine hydrochloride
参考文献
Weygand; Bauer
Justus Liebigs Annalen der Chemie, 1927 , vol. 459, p. 143
反应条件
1: diethyl ether
2: CrO3; acetic acid
View Scheme
参考文献
Gruenanger
Gazzetta Chimica Italiana, 1954 , vol. 84, p. 359,367
反应条件
1: diethyl ether
2: CrO3; acetic acid
View Scheme
参考文献
Gruenanger
Gazzetta Chimica Italiana, 1954 , vol. 84, p. 359,367
反应条件
1: bei der Darstellung laesst sich die Ausbeute durch Destillation im Hochvakuum verbessern
2: methanol; hydroxylamine hydrochloride
View Scheme
参考文献
Weygand; Bauer
Justus Liebigs Annalen der Chemie, 1927 , vol. 459, p. 143
参考文献
Baranski, Andrzej; Cholewka, Elzbieta
Polish Journal of Chemistry, 1991 , vol. 65, # 1 p. 129 - 135
参考文献
Pond; Schoffstall
Journal of the American Chemical Society, 1900 , vol. 22, p. 677
