4-氨基-8-[3,4-二羟基-5-(羟基甲基)四氢呋喃-2-基]-5-氧代吡啶并[6,5-d]嘧啶-6-甲酰胺合成路线 （共 3 条）
反应条件
1: With Raney Ni in ethanol
Reflux;
2: With ammonia in methanol
16 h; Product distribution / selectivity;
参考文献
LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John
Patent: WO2012/158197 A2, 2012 ;
Location in patent: Page/Page column 107 ;
反应条件
1.1: 16 h / 110 - 115 °C
2.1: dowtherm A / 2 h / 240 - 245 °C
2.2: 2 h / 110 °C
3.1: 2.5 h / 185 - 195 °C / 6 - 7.5 Torr
4.1: Raney Ni / ethanol / Reflux
4.2: 16 h
View Scheme
参考文献
LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John
Patent: WO2012/158197 A2, 2012 ;
反应条件
1.1: dowtherm A / 2 h / 240 - 245 °C
1.2: 2 h / 110 °C
2.1: 2.5 h / 185 - 195 °C / 6 - 7.5 Torr
3.1: Raney Ni / ethanol / Reflux
3.2: 16 h
View Scheme
参考文献
LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John
Patent: WO2012/158197 A2, 2012 ;
