3-(4-氯苯基)-1-苯基-1H-吡唑-4-甲醛合成路线 （共 20 条）
反应条件
1: 83 percent / pyridine; piperidine / 4 h / Heating 2: 58 percent / NaOH; hydrazine hydrate / Renay nickel / ethanol / Heating View Scheme
参考文献
Bernard; Hulley; Molenda; Stochla; Wrzeciono
Die Pharmazie, 1986 , vol. 41, # 8 p. 560 - 562
反应条件
triethylamine-formic acid T=95 - 100°C; 2 h;
参考文献
Jagath Reddy; Srinivasa Rao; Khalilullah; Thirupathaiah; Latha
Heterocyclic Communications, 2006 , vol. 12, # 6 p. 423 - 426
参考文献
Bernard; Hulley; Molenda; Stochla; Wrzeciono
Die Pharmazie, 1986 , vol. 41, # 8 p. 560 - 562
反应条件
1: para-chloroacetophenone; phenylhydrazine With acetic acid in ethanol
Heating;
2: N,N-dimethyl-formamide With trichlorophosphate
T=10°C; Vilsmeier-Haack Formylation; Heating;
参考文献
Nasrullah, Muhammad; Khan, Misbahul Ain; Khan, Muhammad Naeem; Humphrey, Mark G. Humphrey; Nasim, Faizul Hassan; Chaudhry, Faryal; Abidi, Moeena Ghazal; Farooq, Umar; Munawar, Munawar Ali
Asian Journal of Chemistry, 2013 , vol. 25, # 1 p. 419 - 423
反应条件
in N,N-dimethyl-formamide
T=70 - 80°C; Vilsmeier-Haack Formylation; 6 h;
参考文献
Gawande, Shrikant S.; Warangkar, Suchita C.; Bandgar, Babasaheb P.; Khobragade, Chandrahasya N.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 10 p. 2772 - 2777
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; iron(III) chloride in water; ethyl acetate
T=20°C; 4 h;
参考文献
Kumar, R. Senthil; Karthikeyan; Perumal, Paramasivan T.
Canadian Journal of Chemistry, 2008 , vol. 86, # 7 p. 720 - 725
反应条件
1.1: 25 °C
1.2: dimethylformamide / 16 h / 20 °C
2.1: aq. Na2CO3
View Scheme
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Synlett, 2004 , # 13 p. 2299 - 2302
反应条件
2: trichlorophosphate
View Scheme
参考文献
Sonika; Meenakshi; Malhotra, Rajesh
Synthetic Communications, 2011 , vol. 41, # 1 p. 136 - 146
反应条件
trichlorophosphate
T=0 - 83°C; Vilsmeier-Haack Formylation; 2.5 h;
参考文献
Paul, Nidhin; Muthusubramanian, Shanmugam
Helvetica Chimica Acta, 2013 , vol. 96, # 3 p. 452 - 457
反应条件
1: sodium acetate / ethanol / 3 h / 50 - 60 °C
2: trichlorophosphate / 6 h / 50 - 60 °C / Cooling
View Scheme
参考文献
Li, Xi; Lu, Xiang; Xing, Man; Yang, Xian-Hui; Zhao, Ting-Ting; Gong, Hai-Bin; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3589 - 3593
