4-硝基-异吲哚啉-1-酮合成路线 （共 4 条）
反应条件
ammonia in methanol T=20°C; 2.5 h;
参考文献
NANJING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD.; YAN, Rong; YANG, Hao; XU, Yongxiang
Patent: WO2010/139266 A1, 2010 ;
Location in patent: Page/Page column 37-38 ;
反应条件
1: 98 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CH2Cl2 / 16 h / Heating 2: 81 percent / ammonia / methanol / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 81 - 85
反应条件
ammonium formate; palladium-carbon in methanol T=35°C; 2 h;
参考文献
NANJING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD.; YAN, Rong; YANG, Hao; XU, Yongxiang
Patent: WO2010/139266 A1, 2010 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1: 83 percent / ammonium formate / Pd/C / dimethylformamide / 0.5 h / 100 °C
2: aq. NaHCO3 / ethyl acetate / 0.5 h / 20 °C
3: NaOH / methanol / 20 °C
View Scheme
参考文献
Jagtap, Prakash G.; Southan, Garry J.; Baloglu, Erkan; Ram, Siya; Mabley, Jon G.; Marton, Anita; Salzman, Andrew; Szabo, Csaba
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 81 - 85
