2-羟基甲基-1,4-苯二恶合成路线 （共 30 条）
反应条件
lipase PS immobilized on Toyonite with MeCO2(CH2)6Si(OMe)3 in dichloromethane T=0°C; Enzymatic reaction; Product distribution; Further Variations:ReagentsTemperatures;
参考文献
Sakai, Takashi; Hayashi, Kyoko; Yano, Fumika; Takami, Mie; Ino, Megumi; Korenaga, Toshinobu; Ema, Tadashi
Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 7 p. 1441 - 1446
反应条件
thionyl chloride in toluene 6 h; Heating;
参考文献
Hoechst Aktiengesellschaft
Patent: US4470989 A1, 1984 ;
反应条件
1: pyridine 2: NaN3 3: H2 / Pd/C 4: Et3N 5: SnCl4 View Scheme
参考文献
Xian, Ming; Li, Xiaopeng; Tang, Xiaoping; Chen, Xinchao; Zheng, Zhongling; Galligan, James J; Kreulen, David L; Wang, Peng G
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2377 - 2380
反应条件
N-bromosuccinmide; triphenylphosphine in N,N-dimethyl-formamide T=40°C; Bromination; 6 h;
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
in hexane; acetonitrile
参考文献
Ciba-Geigy Corporation
Patent: US5120758 A1, 1992 ;
US 5120758 A
反应条件
triethylamine; di(n-butyl)tin oxide in dichloromethane
T=20°C; 6 h;
参考文献
Martinelli, Michael J.; Vaidyanathan, Rajappa; Pawlak, Joseph M.; Nayyar, Naresh K.; Dhokte, Ulhas P.; Doecke, Christopher W.; Zollars, Lisa M. H.; Moher, Eric D.; Khau, Vien Van; Kosmrlj, Berta
Journal of the American Chemical Society, 2002 , vol. 124, # 14 p. 3578 - 3585
反应条件
1: pyridine / 0 - 20 °C
2: ethanol / |Reflux
View Scheme
参考文献
Liu, Xin; Wang, Songlin; Chen, Yin; Liu, Xinghua; Xu, Xiangqing; Liu, Bi-Feng; Zhang, Guisen
Archiv der Pharmazie, 2014 , vol. 347, # 1 p. 32 - 41
反应条件
triethylamine in dichloromethane
T=20°C; 1 h;
参考文献
Bolchi, Cristiano; Fumagalli, Laura; Moroni, Barbara; Pallavicini, Marco; Valoti, Ermanno
Tetrahedron Asymmetry, 2003 , vol. 14, # 23 p. 3779 - 3785
反应条件
1: 96 percent / NBS; PPh3 / dimethylformamide / 6 h / 40 °C
2: 60 percent / dimethylsulfoxide / 72 h / 65 °C
3: 92 percent / H2; conc. HCl / 10 percent Pd-C / methanol / 20 °C / 760 Torr
View Scheme
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
dirhodium tetraacetate in dichloromethane
T=20°C; 0.333333 h;
参考文献
Aventis Pharmaceuticals Inc.
Patent: US2005/26916 A1, 2005 ;
Location in patent: Page/Page column 84 ;
