1: water / Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge 2: zinc; hydrogen chloride; ethanol View Scheme

potassium hydroxide

sulfuric acid Erwaermen des Reaktionsprodukts mit wss. Natronlauge;

1: methanol. sodium methylate 2: aqueous KOH View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '21729736', constants.ctx, '0')">palladium 10 on activated carbon</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=20&deg;C;&nbsp;P=1034.32&nbsp;Torr;&nbsp;<br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '385838', constants.ctx, '0')">ethyl acetoacetate</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3556712', constants.ctx, '0')">potassium <i>tert</i>-butylate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '906698', constants.ctx, '0')"><i>tert</i>-butyl alcohol</a> <br />T=0&deg;C;&nbsp;0.5&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '606667', constants.ctx, '0')">p-methoxybenzyl chloride</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '906698', constants.ctx, '0')"><i>tert</i>-butyl alcohol</a> <br />T=70&deg;C;&nbsp;18&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209232', constants.ctx, '0')">chloro-trimethyl-silane</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8127930', constants.ctx, '0')">sodium iodide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '741857', constants.ctx, '0')">acetonitrile</a> <br />&nbsp;6 h, room temperature, then 10 h , 60 deg C;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3593646', constants.ctx, '0')">sodium ethanolate</a> <br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '741857', constants.ctx, '0')">acetonitrile</a> <br /> <br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: piperidinium acetate / toluene / 16 h / |Dean-Stark; |Reflux<br />2: palladium 10 on activated carbon; hydrogen / methanol / 20 &deg;C / 1034.32 Torr<br /> <br /> &nbsp;