(S)-3-羟基-3-苯基丙酸合成路线 （共 64 条）
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0°C; 3 h;
参考文献
Yan, Tu-Hsin; Hung, An-Wei; Lee, Hui-Chun; Chang, Chii-Shin; Liu, Wen-Hung
Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3301 - 3306
反应条件
triethylamine; B-chloro-diisopinocampheylborane in tetrahydrofuran T=0°C;
参考文献
Wang, Zhe; Zhao, Chunlin; Pierce, Michael E.; Fortunak, Joseph M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 2 p. 225 - 228
反应条件
1: With D-glucose; D-glucose dehydrogenase; alcohol dehydrogenase YMR226c from Saccharomyces cerevisiae; NADPH in dimethyl sulfoxide T=20°C; pH=7.0; 48 h; potassium phosphate bufferEnzymatic reaction; 2: With nitrilase from Bradyrhizobium japonicum strain USDA110 in dimethyl sulfoxide T=30°C; pH=7.2; 24 h; potassium phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ankati, Haribabu; Zhu, Dunming; Yang, Yan; Biehl, Edward R.; Hua, Ling
Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1658 - 1662
反应条件
water; sodium hydroxide in tetrahydrofuran 2 h; Reflux;
参考文献
Khatik, Gopal L.; Kumar, Varun; Nair, Vipin A.
Organic Letters, 2012 , vol. 14, # 10 p. 2442 - 2445
反应条件
lithium hydroxide hydrate; dihydrogen peroxide in tetrahydrofuran; water T=20°C; 6 h;
参考文献
Zhao, Lei; Ma, Yudao; Duan, Wenzeng; He, Fuyan; Chen, Jianqiang; Song, Chun
Organic Letters, 2012 , vol. 14, # 22 p. 5780 - 5783
反应条件
potassium hydroxide in methanol T=0°C; 0.75 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 103, # 8 p. 2127 - 2129
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 3 h;
参考文献
Nishimura, Takahiro; Kasai, Atsuyuki; Nagaosa, Makoto; Hayashi, Tamio
Chemical Communications, 2011 , vol. 47, # 37 p. 10488 - 10490
反应条件
1: 1) chiral borane complex I, 2) n-Bu4NF / 1) THF, EtNO2, -78 deg C, 1h, 2) THF 2: KOH / methanol / 4 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 34 p. 4927 - 4930
反应条件
6.5 h; Ambient temperaturephosphate buffer pH 7, lipase PS-30 from Pseudomonas sp.;
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4289 - 4292
反应条件
peracetic acid; disodium hydrogenphosphate in dichloromethane; acetic acid 5 h;
参考文献
Journal of the American Chemical Society, , vol. 103, p. 3099
