1-二苯甲基氮杂环丁烷-3-甲酸合成路线 （共 6 条）
反应条件
1: With potassium hydroxide; water in 2-methoxy-ethanol T=100°C; 4 h; 2: With hydrogenchloride in 2-methoxy-ethanol; water pH=5;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 48 ;
EP 2119706 A1
反应条件
sodium hydroxide in tetrahydrofuran; methanol
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 20.5 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2008/214815 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
1: With sulfuric acid 1 h; Reflux; 2: With sodium hydrogencarbonate in chloroform; water
参考文献
Kato, Shiro; Harada, Hiroshi; Yamazaki, Hiroshi; Kan, Yoko; Hirokawa, Yoshimi; Nakamura, Takanori
Patent: US2010/249399 A1, 2010 ;
Location in patent: Page/Page column 21 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/72353 A1, 2006 ;
Location in patent: Page/Page column 53 ;
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=20°C; 1 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/49605 A1, 2005 ;
Location in patent: Page/Page column 111; 112; 140 ;
