copper(l) iodide; lithium bromide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine in tetrahydrofuran T=90°C; 8 h;

1: phosphorus oxychloride / 0 - 50 °C 2: 70 percent / NaOH / tetrabutylammonium hydrogen sulfate / dioxane; H2O / 0.5 h / Heating 3: 54 percent / CuI; LiBr / PdCl2(PPh3)2; PPh3 / tetrahydrofuran / 8 h / 90 °C View Scheme

1: 70 percent / NaOH / tetrabutylammonium hydrogen sulfate / dioxane; H2O / 0.5 h / Heating 2: 54 percent / CuI; LiBr / PdCl2(PPh3)2; PPh3 / tetrahydrofuran / 8 h / 90 °C View Scheme

1: K2CO3 / butan-2-one 2: PPh3; CuI; NEt3 / (PPh3)2PdCl2 View Scheme

1: K2CO3 / butan-2-one 2: PPh3; CuI; NEt3 / (PPh3)2PdCl2 View Scheme