1-溴-4-碘-2-三氟甲基苯合成路线 （共 4 条）
反应条件
1: With sulfuric acid; water T=-10°C; 2: With copper; potassium iodide; sodium nitrite in water T=-8 - 102°C; 2.16667 h;
参考文献
UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA; UNIVERSITÉ DE GENÈVE; UNIVERSITÉ CLAUDE BERNARD - LYON 1; GAMBACORTI-PASSERINI, Carlo; MOLOGNI, Luca; SCAPOZZA, Leonardo; BISSON, William; AHMED, Shaheen; GOEKJIAN, Peter; TARDY, Sébastien; ORSATO, Alexandre; GUEYRARD, David; BENOIT, Joseph
Patent: WO2013/167730 A1, 2013 ;
Location in patent: Page/Page column 90 ;
反应条件
1: sulfuric acid; fuming nitric acid 2: SnCl2; aq.-ethanolic HCl 3: aqueous sulfuric acid; sodium nitrite / Erwaermen der Reaktionsloesung mit Kaliumjodid und Kupfer-Pulver View Scheme
参考文献
McBee et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3932
反应条件
1: SnCl2; aq.-ethanolic HCl 2: aqueous sulfuric acid; sodium nitrite / Erwaermen der Reaktionsloesung mit Kaliumjodid und Kupfer-Pulver View Scheme
参考文献
McBee et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3932
反应条件
1: 1-bromo-4-iodo-2-(trifluoromethyl)benzene With n-butyllithium in diethyl ether; hexane T=-70°C; 0.5 h; Inert atmosphere; 2: With tri-isopropoxy-borane in diethyl ether; hexane T=-70°C; 0.25 h; 3: carbon dioxide Further stages;
参考文献
Kurach, Pawel; Lulinski, Sergiusz; Serwatowski, Janusz
European Journal of Organic Chemistry, 2008 , # 18 p. 3171 - 3178
