5-乙酰基-2-甲基吡啶合成路线 （共 36 条）
反应条件
sulfuric acid in toluene T=80°C; 3 h; Inert atmosphere;
参考文献
RSC Advances, , vol. 3, # 40 p. 18544 - 18549
反应条件
1: With sodium hydride in ethyl acetate; N,N-dimethyl-formamide; toluene T=80°C; 10 h; 2: With sulfuric acid in water T=110°C; 2 h; 3: With potassium carbonate in water pH=9;
参考文献
EP2417973 A1, ;
Page/Page column 6-7; 15 ;
反应条件
1: With sodium hydride in N,N-dimethyl-formamide; toluene T=80°C; 10 h; 2: With sulfuric acid in water T=110°C; 2 h; 3: With potassium carbonate in water pH=9;
参考文献
US2012/122914 A1, ;
Page/Page column 5 ;
反应条件
1: With sulfuric acid; acetic anhydride; acetic acid 2: With chromium(VI) oxide T=10 - 20°C; 3: With sodium carbonate in water
参考文献
WO2010/67085 A2, ;
Page/Page column 58 ;
反应条件
in tetrahydrofuran; hexane T=0 - 20°C; 16 h;
参考文献
WO2008/32204 A1, ;
Page/Page column 38 ;
WO 2008/032204 A1
反应条件
tetrakis(triphenylphosphine) palladium(0); cesium fluoride in 1,2-dichloro-ethane T=75°C; 6 h; Inert atmosphereSealed tube;
参考文献
Organic Letters, , vol. 16, # 3 p. 824 - 827
反应条件
1: With sodium hydride in N,N-dimethyl-formamide; toluene T=80°C; 2.5 h; 2: With sulfuric acid; water 2 h; Heating / reflux; 3: With water; potassium carbonate T=0°C; Product distribution / selectivity;
参考文献
WO2008/70350 A2, ;
Page/Page column 35-36 ;
反应条件
1.1: piperidine; tris(4-methylphenyl)-phosphine / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / Inert atmosphere 1.2: 40 °C 1.3: 2 h / Reflux 2.1: sulfuric acid / toluene / 50 °C View Scheme
反应条件
1.1: pyridine / dichloromethane / 1.5 h / 0 °C 2.1: piperidine; tris(4-methylphenyl)-phosphine / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / Inert atmosphere 2.2: 40 °C 2.3: 2 h / Reflux 3.1: sulfuric acid / toluene / 50 °C View Scheme
反应条件
sulfuric acid 2 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063
