2-氯-4,4,4-三氟乙酰乙酸乙酯合成路线

372-31-6三氟乙酰乙酸乙酯→363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯

参考文献

Dow AgroSciences LLC
Patent: US6372769 B1, 2002 ;
Location in patent: Page column 4 ;

参考文献

Sevenard, Dmitri V.; Vorobyev, Mikhail; Sosnovskikh, Vyacheslav Ya.; Wessel, Helma; Kazakova, Olesya; Vogel, Vera; Shevchenko, Nikolay E.; Nenajdenko, Valentine G.; Lork, Enno; Roeschenthaler, Gerd-Volker
Tetrahedron, 2009 , vol. 65, # 36 p. 7538 - 7552

1522-43-6→363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯+196698-26-7

参考文献

Tetrahedron, , vol. 65, # 36 p. 7538 - 7552

363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯→431-37-81-氯-3,3,3-三氟丙酮

参考文献

Cherbuliez,E. et al.
Helvetica Chimica Acta, 1965 , vol. 48, p. 1423 - 1426

363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯+17356-08-0→344-72-92-氨基-4-三氟甲基噻唑-5-甲酸乙酯

参考文献

SCHERING CORPORATION; TING, Pauline, C.; ASLANIAN, Robert, G.; CAPLEN, Mary Ann; CAO, Jianhua; KIM, David, Won-Shik; KIM, Hyunjin; KUANG, Rongze; LEE, Joe, F.; SCHWERDT, John, H.; WU, Heping; ZHOU, Gang; ZORN, Nicolas
Patent: WO2010/59606 A2, 2010 ;
Location in patent: Page/Page column 169 ;

363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯→344-72-92-氨基-4-三氟甲基噻唑-5-甲酸乙酯

参考文献

Ting, Pauline C.; Aslanian, Robert; Caplen, Mary Ann; Cao, Jianhua; Chan, Tin-Yau; Kim, David; Kim, Hyunjin; Kim, Jae-Hun; Kuang, Rongze; Lee, Joe F.; Schwerdt, John; Wu, Heping; Zorn, Nicolas
Patent: US2011/224137 A1, 2011 ;
US 20110224137 A1

2114-15-0丁烷-2-基氨基甲酸酯+363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯→78451-14-6乙基2-氯-4-(三氟甲基)恶唑-5-羧酸酯

参考文献

Monsanto Company
Patent: US4303439 A1, 1981 ;

363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯→72850-79-42-溴-4-三氟甲基噻唑-5-甲酸乙酯

参考文献

Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630

363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯+463-52-5甲脒→55942-41-14-(三氟甲基)-1H-咪唑-5-羧酸乙酯

参考文献

ELBION GMBH; WYETH
Patent: US2009/143361 A1, 2009 ;
Location in patent: Page/Page column 33 ;
US 20090143361 A1

363-58-62-氯-4,4,4-三氟乙酰乙酸乙酯+77287-34-4甲亚胺酸→55942-41-14-(三氟甲基)-1H-咪唑-5-羧酸乙酯

参考文献

Zuev, Dmitry; Vrudhula, Vivekananda M.; Michne, Jodi A.; Dasgupta, Bireshwar; Pin, Sokhom S.; Huang, Xiaohua Stella; Wu, Dedong; Gao, Qi; Zhang, Jie; Taber, Matthew T.; MacOr, John E.; Dubowchik, Gene M.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3669 - 3674