(R)-(+)-N-乙酰基-甲基苄胺合成路线 （共 87 条）
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 30, # 22 p. 2967 - 2970
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 5 p. 1009 - 1027
反应条件
1: With hydrogenchloride; methanol; water T=80°C; 15 h; 2: With water; sodium hydroxide
参考文献
Postech Academy-Industry Foundation
Patent: US7592488 B2, 2009 ;
Location in patent: Page/Page column 19-20 ;
反应条件
N-Benzyldiacetamide; potassium hydride in diethylene glycol dimethyl ether T=120°C; 18 h;
参考文献
Bell, Christen M.; Kissounko, Denis A.; Gellman, Samuel H.; Stahl, Shannon S.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 5 p. 761 - 763
反应条件
1.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 4 h / 20 - 60 °C 2.1: sodium hypochlorite; sodium hydroxide / methanol; water / 2 h / 20 - 60 °C 3.1: ruthenium on carbon; ammonia; hydrogen / water / 144 h / 90 - 150 °C / 52505.3 Torr 4.1: sodium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C 4.2: 48 h / 20 °C 4.3: 3 - 4 h 5.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere View Scheme
参考文献
Paleek, Jii; Zweigerdt, Robert; Olmer, Ruth; Martin, Ulrich; Kirschning, Andreas; Draeger, Gerald
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 15 p. 5503 - 5510
反应条件
N-Benzyldiacetamide; potassium hydride in diethylene glycol dimethyl ether T=120°C; 18 h;
参考文献
Bell, Christen M.; Kissounko, Denis A.; Gellman, Samuel H.; Stahl, Shannon S.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 5 p. 761 - 763
反应条件
1.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 4 h / 20 - 60 °C
2.1: sodium hypochlorite; sodium hydroxide / methanol; water / 2 h / 20 - 60 °C
3.1: ruthenium on carbon; ammonia; hydrogen / water / 144 h / 90 - 150 °C / 52505.3 Torr
4.1: sodium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C
4.2: 48 h / 20 °C
4.3: 3 - 4 h
View Scheme
参考文献
Paleek, Jii; Zweigerdt, Robert; Olmer, Ruth; Martin, Ulrich; Kirschning, Andreas; Draeger, Gerald
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 15 p. 5503 - 5510
