1-(4-甲氧基苯基)-1-环己烷甲腈合成路线 (共 6 条)
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 1.78333 - 1.8 h;
参考文献
TOPOTARGET UK LIMITED
Patent: WO2004/65354 A1, 2004 ;
Location in patent: Page 103; 114; 71; 75 ;
反应条件
1: cyclohexane carbonitrile With TMPZnCl*LiCl in tetrahydrofuran T=25°C; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene With palladium diacetate in tetrahydrofuran T=50°C; 3 h; Inert atmosphere;
参考文献
Duez, Stephanie; Bernhardt, Sebastian; Heppekausen, Johannes; Fleming, Fraser F.; Knochel, Paul
Organic Letters, 2011 , vol. 13, # 7 p. 1690 - 1693
反应条件
tris(dibenzylideneacetone)dipalladium (0); ZnF2; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide T=90°C; 24 h;
参考文献
Wu, Lingyun; Hartwig, John F.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15824 - 15832
反应条件
indium tribromide in dichloromethane T=20°C; Inert atmosphere;
参考文献
Chen, Gang; Wang, Zheng; Wu, Jiang; Ding, Kuiling
Organic Letters, 2008 , vol. 10, # 20 p. 4573 - 4576
反应条件
1: trimethylsilyl cyanide With trifluorormethanesulfonic acid in 2,3,4-trifluorotoluene T=-20°C; 0.0833333 h; Inert atmosphere; 2: 4'-methoxy-2,3,4,5-tetrahydro-1,1'-biphenyl in 2,3,4-trifluorotoluene T=-20 - -5°C; Inert atmosphere;
参考文献
Yanagisawa, Arata; Nezu, Tetsuya; Mohri, Shin-Ichiro
Organic Letters, 2009 , vol. 11, # 22 p. 5286 - 5289
反应条件
1: With sodium hydroxide; dihydrogen peroxide in trans-1,3-dioxane; water
96 h; Heating / reflux;
2: With hydrogenchloride in trans-1,3-dioxane; water
pH=1;
参考文献
TOPOTARGET UK LIMITED
Patent: WO2004/65354 A1, 2004 ;
Location in patent: Page 103; 104; 115; 71; 75 ;