反应条件
1: 59 percent / NaNH2 / tetrahydrofuran / 1.5 h / 5 - 22 °C
2: 66 percent / H2, (η6-PhCO2Me)Cr(CO)3 / acetone / 2 h / 120 - 125 °C / 60800 Torr
3: NaBH4 / ethanol; H2O / Ambient temperature
4: aq. KOH / 0.5 h / Ambient temperature
5: 1.) 2,2'-dipyridyl disulfide, PPh3, 2.) AgClO4 / 1.) CH3CN, from 20 deg C to 25 deg C, 2 h, 2.) CH3CN, p-xylene, reflux, 6 h
View Scheme
参考文献
Vasil'ev, Andrei A.; Vlasyuk, Alexei L.; Gamalevich, Galina D.; Serebryakov, Edward P.
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 3 p. 389 - 400
