N-乙酰基-L-丙氨酸甲酯合成路线 （共 24 条）
反应条件
{(1,5-cyclooctadiene)Rh(1,2-bis((2S,5S)-2,5-diethylphospholano)benzene)}triflate; hydrogen in methanol T=20 - 25°C; P=1551.4 Torr;
参考文献
Reetz, Manfred T.; Bondarev, Oleg G.; Gais, Hans-Joachim; Bolm, Carsten
Tetrahedron Letters, 2005 , vol. 46, # 34 p. 5643 - 5646
反应条件
hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; (R,R)-BICP in tetrahydrofuran T=20°C; P=750.075 Torr; 24 h;
参考文献
THE PENN STATE RESEARCH FOUNDATION
Patent: EP918781 B1, 2004 ;
Location in patent: Page 10 ;
反应条件
1: L-alanine methyl ester hydrochloride With triethylamine in dichloromethane T=0 - 20°C; 2: acetyl chloride in dichloromethane T=20°C; 3 h;
参考文献
Croft; Foley
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 9 p. 1594 - 1600
反应条件
deuterium hydride; Ru(OCOCH3)2((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) in methanol-d1 T=30°C; P=760.051 Torr; 81 h; Further byproducts. Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 23 p. 6649 - 6667
反应条件
in dichloromethane T=20°C; 4 h;
参考文献
Stueckler, Clemens; Winkler, Christoph K.; Hall, Melanie; Hauer, Bernhard; Bonnekessel, Melanie; Zangger, Klaus; Faber, Kurt
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1169 - 1173
反应条件
tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0) in dichloromethane 0.0833333 h;
参考文献
Roos; Bernabe; Hiemstra; Speckamp; Kaptein; Boesten
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1733 - 1740
反应条件
(cycloocta-1,5-diene)-[(S,S)-2,2'-bis(ferrocenyl-phenylphosphino)-1,1'-biphenyl] rhodium tetrafluoroborate; hydrogen in dichloromethane T=20°C; 16 h; Autoclave; Solvent;
参考文献
WO2013/7724 A1, ;
Page/Page column 88; 89; 90 ;
反应条件
1: α-acetylaminoacrylic acid With hydrogen; BINAP-RuCl2*dmf in methanol T=50°C; Catalytic hydrogenation; P=7500.6 Torr; 2: methanol With thionyl chloride Esterification; 2 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 41, # 18 p. 3323 - 3326
反应条件
1: H2; N-Ph2P-N-methyl-(R)-1-((S)-2-Ph2P-ferrocenyl)ethylamine / Rh(1,5-cyclooctadiene)2OTf / tetrahydrofuran / 24 h / 25 °C / 517.15 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 5 p. 1872 - 1880
反应条件
in pyridine T=99.84°C; 2 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 3 p. 405 - 410
