N-乙酰-L-苯丙氨酸甲酯合成路线 （共 84 条）
反应条件
{(1,5-cyclooctadiene)Rh(1,2-bis((2S,5S)-2,5-diethylphospholano)benzene)}triflate; hydrogen in methanol T=20 - 25°C; P=1551.4 Torr;
参考文献
Bunlaksananusorn, Tanasri; Polborn, Kurt; Knochel, Paul
Angewandte Chemie - International Edition, 2003 , vol. 42, # 33 p. 3941 - 3943
反应条件
bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; (R)-BINOL-(S)-phenyl-(S)-methyl-N-phoshino sulfoximine; hydrogen in dichloromethane T=20°C; P=975.078 Torr; 20 h;
参考文献
UMICORE AG and CO. KG
Patent: WO2005/108409 A2, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
in dichloromethane T=20°C; 4 h;
参考文献
De Marco, Rosaria; Gioia, Maria Luisa Di; Leggio, Antonella; Liguori, Angelo; Viscomi, Maria Caterina
European Journal of Organic Chemistry, 2009 , # 22 p. 3795 - 3800
参考文献
Diaz, David D.; Finn
Chemistry - A European Journal, 2004 , vol. 10, # 1 p. 303 - 309
反应条件
hydrogen; (S,S)-(-)-1-r,2-c,5-t-triphenylphospholane; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate in methanol T=20°C; P=760 Torr; 0.333333 h;
参考文献
THE PENN STATE RESEARCH FOUNDATION
Patent: EP918781 B1, 2004 ;
Location in patent: Page 10 ;
反应条件
(R,R-iPr-Duphos)Co(CH2SiMe3)2; hydrogen in tetrahydrofuran T=22°C; P=25841.7 Torr; 12 h; enantioselective reaction;
参考文献
Friedfeld, Max R.; Shevlin, Michael; Hoyt, Jordan M.; Krska, Shane W.; Tudge, Matthew T.; Chirik, Paul J.
Science, 2013 , vol. 342, # 6162 p. 1076 - 1080
反应条件
bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; (S)-BINOL-(S)-phenyl,methyl N-phoshino sulfoximine; hydrogen in dichloromethane T=20°C; P=975.078 Torr; 20 h;
参考文献
Tetrahedron Letters, , vol. 46, # 34 p. 5643 - 5646
反应条件
hydrogen; (Rc,SFe,Sp)-2-[1-[(N-methyl-N-diphenylphosphino)amino]ethyl]-1-[(2-methoxyphenyl)phenylphosphino]ferrocene; bis(1,5-cyclooctadiene)rhodium trifluoromethanesulfonate in tetrahydrofuran T=20°C; P=5171.62 Torr; 2 h; Conversion of starting material;
参考文献
WO2005/68477 A1, ;
Page/Page column 86; 89 ;
反应条件
1: With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-MethylBoPhos in tetrahydrofuran T=25°C; 0.25 h; 2: methyl 2-acetamidocinnamate With hydrogen in tetrahydrofuran P=1277.21 - 1794.37 Torr; 6 h; Product distribution / selectivity;
参考文献
US6906213 B1, ;
Page/Page column 14-15 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
Crich, David; Sharma, Indrajeet
Angewandte Chemie, International Edition, 2009 , vol. 48, # 41 p. 7591 - 7594
