3-(4-氯苯基)-2-羟基-丙烯酸合成路线 （共 16 条）
反应条件
hydrogenchloride in tetrahydrofuran 10 h; Heating / reflux;
参考文献
Northwest University
Patent: EP2019090 A1, 2009 ;
Location in patent: Page/Page column 8 ;
反应条件
sodium hydroxide in tetrahydrofuran 5 h; Ambient temperature;
参考文献
Simchen, Gerhard; Siegl, Gerald
Liebigs Annalen der Chemie, 1992 , # 6 p. 607 - 614
反应条件
1: 94 percent / acetic anhydride; sodium acetate / 0.07 h / microwave irradiation 2: aq. HCl / Heating View Scheme
参考文献
Holla; Gonsalves; Shivananda
Bollettino Chimico Farmaceutico, 1998 , vol. 137, # 3 p. 93 - 96
反应条件
diaphorase; 2,6-Dichloroindophenol; potassium chloride; oxygen; β-nicotinamide adenine dinucleotide T=15 - 20°C; pH=9.5; aq. bufferEnzymatic reaction;
参考文献
Paradisi, Francesca; Conway, Philip A.; Maguire, Anita R.; Engel, Paul C.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 19 p. 3611 - 3615
反应条件
1: With sodium hydroxide T=80°C; 2: With hydrogenchloride 5 h; Heating;
参考文献
Liu, Si-Jie; Cui, Li-Bo; Xu, Hui-Lan; Wang, Tie-Ying; Hu, Chun; Li, Shuo; Lin, Huang-Quan; Wan, David Chicheong
Heterocycles, 2013 , vol. 87, # 12 p. 2607 - 2614
反应条件
lithium hydroxide hydrate in water
参考文献
Luettenberg, Sebastian; Ta, Tien Dat; Von Der Heyden, Jan; Scherkenbeck, Juergen
European Journal of Organic Chemistry, 2013 , # 9 p. 1824 - 1830
反应条件
1: hydrogenchloride / water / 0.5 h / 20 °C 2: lithium hydroxide hydrate / water View Scheme
参考文献
Luettenberg, Sebastian; Ta, Tien Dat; Von Der Heyden, Jan; Scherkenbeck, Juergen
European Journal of Organic Chemistry, 2013 , # 9 p. 1824 - 1830
反应条件
1: CF3COOH / 2 h / Heating 2: 82 percent / 1N aq. NaOH / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Simchen; Siegl
Synthesis, 1989 , # 12 p. 945 - 946
反应条件
1: 12 h / Heating 2: aq. TFA / 24 h / 23 °C View Scheme
参考文献
Nicolaou; Hughes, Robert; Pfefferkorn, Jeffrey A.; Barluenga, Sofia; Roecker
Chemistry - A European Journal, 2001 , vol. 7, # 19 p. 4280 - 4295
反应条件
potassium hydroxide 6 h; Heating;
参考文献
Pharmazie, 1988 , vol. 43, # 3 p. 166 - 167
