2,5-二氯-3-噻吩甲酸合成路线 （共 13 条）
反应条件
sodium hydroxide; sulfuryl dichloride in tetrahydrofuran; ethanol; acetonitrile
参考文献
Journal of the American Chemical Society, , vol. 69, p. 3096
反应条件
palladium diacetate; sodium peroxodisulphate in acetic acid T=70 - 80°C; 7 h;
参考文献
Itahara, Toshio
Chemistry Letters, 1983 , p. 127 - 128
反应条件
chlorine; acetic acid
参考文献
Journal of the American Chemical Society, , vol. 76, p. 2445
参考文献
Journal of the American Chemical Society, , vol. 71, p. 333
反应条件
chlorine; acetic acid
参考文献
Journal of the American Chemical Society, , vol. 76, p. 2445
反应条件
chlorine; acetic acid
参考文献
Journal of the American Chemical Society, , vol. 76, p. 2445
反应条件
palladium (II) trifluoroacetate; silver carbonate in dimethyl sulfoxide; N,N-dimethyl-formamide T=120°C; 16 h; Inert atmosphere;
参考文献
Cornella, Josep; Lahlali, Hicham; Larrosa, Igor
Chemical Communications, 2010 , vol. 46, # 43 p. 8276 - 8278
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 2.5 h;
参考文献
ELI LILLY AND COMPANY; LEDGARD, Andrew James
Patent: WO2013/9517 A1, 2013 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
palladium on activated charcoal Hydrogenation;
参考文献
Blanchette; Brown
Journal of the American Chemical Society, 1951 , vol. 73, p. 2779
Journal of the American Chemical Society, 1952 , vol. 74, p. 1066
