4-乙酰氨基-N-(2-二乙基氨基乙基)-2-甲氧基苯甲酰胺合成路线 （共 8 条）
反应条件
1: 89 percent / ethanol / 2 h / 50 °C 2: KOH / methanol; H2O / 2 h / Heating 3: 10.2 g / acetic acid / 2 h / 50 °C 4: thionyl chloride / tetrahydrofuran / 2 h / Heating 5: 1.2 g / triethylamine / tetrahydrofuran / 2 h View Scheme
参考文献
Eisenhut; Hull; Mohammed; Mier; Lay; Just; Gorgas; Lehmann; Haberkorn
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3913 - 3922
反应条件
1: 10.2 g / acetic acid / 2 h / 50 °C 2: thionyl chloride / tetrahydrofuran / 2 h / Heating 3: 1.2 g / triethylamine / tetrahydrofuran / 2 h View Scheme
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
反应条件
1: thionyl chloride / tetrahydrofuran / 2 h / Heating 2: 1.2 g / triethylamine / tetrahydrofuran / 2 h View Scheme
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
反应条件
1: KOH / methanol; H2O / 2 h / Heating 2: 10.2 g / acetic acid / 2 h / 50 °C 3: thionyl chloride / tetrahydrofuran / 2 h / Heating 4: 1.2 g / triethylamine / tetrahydrofuran / 2 h View Scheme
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
反应条件
in acetonitrile T=20°C; Acetylation; 1 h;
参考文献
Eisenhut; Hull; Mohammed; Mier; Lay; Just; Gorgas; Lehmann; Haberkorn
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3913 - 3922
反应条件
triethylamine in tetrahydrofuran 2 h;
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
反应条件
1: 12 h / 90 °C 2: acetonitrile / 1 h / 20 °C View Scheme
参考文献
Eisenhut; Hull; Mohammed; Mier; Lay; Just; Gorgas; Lehmann; Haberkorn
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3913 - 3922
反应条件
potassium hydroxide in methanol; water
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
