3-(2-氨基乙基)-6-甲氧基吲哚合成路线 （共 20 条）
反应条件
2: LiAlH4; diethyl ether View Scheme
参考文献
Yakugaku Kenkyu, , vol. 30, p. 194
Chem.Abstr., , p. 1517
反应条件
1: aq.-ethanolic KOH 2: aqueous HCl View Scheme
参考文献
Journal of the Chemical Society, , p. 4593,4597
反应条件
1: aqueous H2SO4 2: palladium powder; maleic acid; H2O View Scheme
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
TEA in tetrahydrofuran 6 h; Ambient temperature;
参考文献
Mor, Marco; Rivara, Silvia; Silva, Claudia; Bordi, Fabrizio; Plazzi, Pier Vincenzo; Spadoni, Gilberto; Diamantini, Giuseppe; Balsamini, Cesarino; Tarzia, Giorgio; Fraschini, Franco; Lucini, Valeria; Nonno, Romolo; Stankov, Bojidar Michaylov
Journal of Medicinal Chemistry, 1998 , vol. 41, # 20 p. 3831 - 3844
反应条件
1: triethylamine / methanol / 16 h / 100 °C / |Inert atmosphere 2: trichlorophosphate / acetonitrile / 3 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Lalonde, Mathieu P.; McGowan, Meredeth A.; Rajapaksa, Naomi S.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2013 , vol. 135, # 5 p. 1891 - 1894
反应条件
sulfuric acid in water T=110°C; 0.333333 h;
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
1: aqueous HCl 2: H3PO4 View Scheme
参考文献
Spenser
Canadian Journal of Chemistry, 1959 , vol. 37, p. 1851,1856
反应条件
sulfuric acid in water
T=110°C; 0.333333 h;
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
1: With sodium acetate
Pictet-Spengler reaction; pH=4.5 - 4.8;
2: With hydrogenchloride
Heating;
3: With palladium on activated charcoal in xylene
Heating;
参考文献
Castro, Alfredo C.; Dang, Luan C.; Soucy, Francois; Grenier, Louis; Mazdiyasni, Hormoz; Hottelet, Maria; Parent, Lana; Pien, Christine; Palombella, Vito; Adams, Julian
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2419 - 2422
反应条件
1: hydrogenchloride / methanol / 20 °C
2: manganese(IV) oxide; 5 Pd(II)/C(eggshell) / N,N-dimethyl-formamide / 150 °C / Microwave irradiation
View Scheme
参考文献
Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis; Liu, Ji-Feng; Lin, Xiangjie; Auerbach, Ken; Ray, Soumya S.; Xian, Jun; Glicksman, Marcie A.; Stein, Ross L.; Higgins, Jonathan M.G.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2015 - 2019
