phosphate buffer; adenosine deaminase in water; dimethyl sulfoxide

1: 95 percent / methanol / 96 h / 27 °C 2: 96 percent / pyridine / 26 h / 25 °C 3: 50 percent / imidazole / dimethylformamide / 27 h / 25 °C 4: dimethylformamide / 100 h / 24 °C 5: n-Bu3SnH, AIBN / toluene / 6 h / Heating 6: TBAF / tetrahydrofuran / 5 h / 22 °C 7: 80percent aq. CH3COOH / 0.5 h / Ambient temperature 8: conc. aq. NH3 / 2 h / 55 °C View Scheme

1: 96 percent / pyridine / 26 h / 25 °C 2: 50 percent / imidazole / dimethylformamide / 27 h / 25 °C 3: dimethylformamide / 100 h / 24 °C 4: n-Bu3SnH, AIBN / toluene / 6 h / Heating 5: TBAF / tetrahydrofuran / 5 h / 22 °C 6: 80percent aq. CH3COOH / 0.5 h / Ambient temperature 7: conc. aq. NH3 / 2 h / 55 °C View Scheme

1: n-Bu3SnH, AIBN / toluene / 6 h / Heating 2: TBAF / tetrahydrofuran / 5 h / 22 °C 3: 80percent aq. CH3COOH / 0.5 h / Ambient temperature 4: conc. aq. NH3 / 2 h / 55 °C View Scheme

1: E. coli BM-11 cells; BMT-4D/1A 2: adenosine deaminase View Scheme

1: E. coli BM-11 cells; BMT-4D/1A 2: adenosine deaminase View Scheme

1: 1.) BSA, TMSOTf / 1.) DCE, 2.) TolH 2: 87 percent / NH4OH / methanol / 48 h / 60 °C 3: 100 percent / adenosine deaminase, phosphate buffer / dimethylsulfoxide; H2O View Scheme

1: 1.) BSA, TMSOTf / 1.) DCE, 2.) TolH 2: 87 percent / NH4OH / methanol / 48 h / 60 °C View Scheme

2: NH3, MeOH / Ambient temperature View Scheme

1: 3'-Deoxyguanosine With chloro-trimethyl-silane in pyridine T=20°C; 0.333333 h; 2: 2-methylpropanoic anhydride in pyridine T=20°C; 2 h;