1: 1,2-difluoro-4-bromobenzene With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.583333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78°C; 0.25 h; 3: With acetic acid in tetrahydrofuran; water T=-78 - 20°C;

1: 1,2-difluoro-4-bromobenzene With lithium diisopropyl amide in tetrahydrofuran; cyclohexane; ethylbenzene T=-70 - -40°C; 1.5 h; 2: 1-piperidinecarboxaldehyde in tetrahydrofuran; cyclohexane; ethylbenzene T=-40°C; 3 h; 3: With water T=0°C;

hydrogenchloride; n-butyllithium; sodium sulfate in tetrahydrofuran; hexane; N,N-dimethyl-formamide

in N-methyl-acetamide

hydrazine in ethylene glycol dimethyl ether 2.5 h; Reflux; Product distribution / selectivity;

sodium tetrahydroborate in methanol