6-溴苯并噻吩-2-羧酸甲酯合成路线 （共 8 条）
反应条件
1: With triethylamine in acetonitrile T=85°C; Inert atmosphere; 2: With sodium hydroxide in acetonitrile
参考文献
NOVARTIS AG; BOCK, Mark Gary; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra
Patent: WO2012/149413 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/149413 A1
反应条件
triethylamine in dimethyl sulfoxide T=80 - 90°C; 2 h;
参考文献
Zuckerman, Nathaniel B.; Kang, Xiongwu; Chen, Shaowei; Konopelski, Joseph P.
Tetrahedron Letters, 2013 , vol. 54, # 11 p. 1482 - 1485
反应条件
1: 2-mercaptoacetic acid methyl ester With sodium hydride in dimethyl sulfoxide T=20°C; 2: 4-Bromo-2-fluoro-benzaldehyde in dimethyl sulfoxide 0.166667 h;
参考文献
Luithle, Joachim; Bob, Frank-Gerhard; Erb, Christina; Schnizler, Katrin; Flessner, Timo; Kampen, Marja van; Methfessel, Christoph
Patent: US2007/37844 A1, 2007 ;
Location in patent: Page/Page column 7 ;
US 20070037844 A1
反应条件
sulfuric acid T=65°C;
参考文献
WO2007/140174 A2, ;
Page/Page column 26-27 ;
参考文献
WO2003/104227 A1, ;
Page 47, 48 ;
反应条件
1: water; lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / isobutyramide / 1 h / 20 - 200 °C / Microwave irradiation View Scheme
参考文献
NOVARTIS AG; BOCK, Mark Gary; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra
Patent: WO2012/149413 A1, 2012 ;
WO 2012/149413 A1
反应条件
LAB in tetrahydrofuran; hexane
0.0833333 h;
参考文献
Zuckerman, Nathaniel B.; Kang, Xiongwu; Chen, Shaowei; Konopelski, Joseph P.
Tetrahedron Letters, 2013 , vol. 54, # 11 p. 1482 - 1485
反应条件
1: LAB / tetrahydrofuran; hexane / 0.08 h
2: triethylamine / dichloromethane / 16 h / 20 °C / |Inert atmosphere
3: lithium triethylborohydride / tetrahydrofuran; hexane / 5 h / 0 - 20 °C
View Scheme
参考文献
Zuckerman, Nathaniel B.; Kang, Xiongwu; Chen, Shaowei; Konopelski, Joseph P.
Tetrahedron Letters, 2013 , vol. 54, # 11 p. 1482 - 1485
