6-氨基吡啶-2-羧酸甲酯合成路线 （共 33 条）
反应条件
hydrogenchloride; iron in methanol 0.666667 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1159 - 1164
反应条件
1: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling 2: toluene / 30 h / 120 °C 3: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 22 p. 6416 - 6418
反应条件
1: 98 percent / TMSCHN2 / hexane / 0 °C 2: Ts2O / various solvent(s); CH2Cl2 / 0.25 h 3: TFA / various solvent(s); CH2Cl2 / 70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557
反应条件
1: Ts2O / various solvent(s); CH2Cl2 / 0.25 h 2: TFA / various solvent(s); CH2Cl2 / 70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557
反应条件
1: ammonia / water / 17 h / 200 °C 2: hydrogenchloride; water / 19 h / Reflux 3: orthoacetic acid trimethyl ester; acetyl chloride / 17 h / Reflux View Scheme
参考文献
Heterocycles, , vol. 83, # 10 p. 2343 - 2352
反应条件
hydrogenchloride T=20°C; 18 h;
参考文献
Organic Process Research and Development, , vol. 14, # 1 p. 263 - 271
反应条件
1: hydrogenchloride; water / 19 h / Reflux 2: orthoacetic acid trimethyl ester; acetyl chloride / 17 h / Reflux View Scheme
参考文献
Heterocycles, , vol. 83, # 10 p. 2343 - 2352
反应条件
in acetonitrile 12 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/140101 A2, 2009 ;
Location in patent: Page/Page column 41-42 ;
WO 2009/140101 A2
反应条件
bromine in chloroform T=20°C;
参考文献
WO2011/75591 A1, ;
Page/Page column 95 ;
反应条件
lithium aluminium tetrahydride
参考文献
JOHNSON and JOHNSON
Patent: WO2004/101533 A1, 2004 ;
Location in patent: Page 79 ;
