6-氨基吡啶-2-羧酸甲酯合成路线 （共 33 条）
反应条件
sulfuric acid Reflux;
参考文献
Le Hir de Fallois, Loic Patrick; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Beck, Brent Christopher
Patent: US2011/152312 A1, 2011 ;
Location in patent: Page/Page column 40 ;
反应条件
acetyl chloride Heating;
参考文献
Ontoria, Jesus M.; Martin Hernando, Jose I.; Malancona, Savina; Attenni, Barbara; Stansfield, Ian; Conte, Immacolata; Ercolani, Caterina; Habermann, Joerg; Ponzi, Simona; Di Filippo, Marcello; Koch, Uwe; Rowley, Michael; Narjes, Frank
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4026 - 4030
反应条件
1: With hydrogenchloride in methanol 18 h; Reflux; 2: With sodium hydrogencarbonate in water
参考文献
F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; FLOHR, Alexander; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew
Patent: WO2011/101304 A2, 2011 ;
Location in patent: Page/Page column 91-92 ;
WO 2011/101304 A2
反应条件
palladium 10 on activated carbon; hydrogen in tetrahydrofuran
参考文献
Zhao, Huaiqing; Ong, Wei Qiang; Fang, Xiao; Zhou, Feng; Hii, Meng Ni; Li, Sam Fong Yau; Su, Haibin; Zeng, Huaqiang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1172 - 1180
反应条件
1: N-(6-methyl-pyridin-2-yl)acetamide With potassium permanganate in water T=75°C; 2: methanol With hydrogenchloride; water 24 h; Reflux; 3: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
EP2098513 A1, ;
Page/Page column 48 ;
EP 2098513 A1
反应条件
1: 100 percent / 1.5 h / 60 - 70 °C 2: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 3: HCl / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4623 - 4633
反应条件
1: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 2: HCl / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4623 - 4633
反应条件
1: sodium hydroxide / water / 12 h / 20 °C 2: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C 3: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling 4: toluene / 30 h / 120 °C 5: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 22 p. 6416 - 6418
反应条件
1: sulfuric acid / 48 h / Reflux 2: sodium hydroxide / water / 12 h / 20 °C 3: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C 4: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling 5: toluene / 30 h / 120 °C 6: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 22 p. 6416 - 6418
反应条件
1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / -10 - -5 °C 2: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling 3: toluene / 30 h / 120 °C 4: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 22 p. 6416 - 6418
