5-氨基吡啶-3-羧酸甲酯合成路线 （共 15 条）
反应条件
thionyl chloride T=0°C; Reflux;
参考文献
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; DAHL, Russell; COSFORD, Nicholas, D.P.; MILLAN, Jose, Luis
Patent: WO2013/126608 A1, 2013 ;
Location in patent: Paragraph 00492-00493 ;
反应条件
hydrogenchloride in methanol T=0 - 75°C; 3 h; Alkaline aqueous solution;
参考文献
E.I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2004/35545 A2, 2004 ;
Location in patent: Page 46 ;
反应条件
in methanol; hexane; toluene T=20°C; 2 h;
参考文献
WO2010/111056 A1, ;
Page/Page column 35-36 ;
WO 2010/111056 A1
反应条件
1: CuSO4*5H2O; aq. NH3 / 24 h / 180 °C 2: 1.82 g / acetic anhydride; various solvent(s) / 48 h / Heating View Scheme
参考文献
Chemistry - A European Journal, , vol. 8, # 5 p. 1218 - 1226
参考文献
WO2009/42694 A1, ;
Page/Page column 95 ;
WO 2009/042694 A1
反应条件
pyridine hydrogenfluoride; sodium nitrite T=0 - 50°C; 1.5 h;
参考文献
ZAPAQ, INC.; THE BOARD OF TRUSTEES OF THE UNVERSITY OF ILLINOIS; OKLAHOMA MEDICAL RESEARCH FOUNDATION
Patent: WO2006/110668 A1, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/110668 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 21 h;
参考文献
CHROMA THERAPEUTICS LTD
Patent: WO2006/117549 A1, 2006 ;
Location in patent: Page/Page column 97 ;
WO 2006/117549 A1
反应条件
1: aqueous alkaline solution 2: aqueous H2SO4 / Diazotization View Scheme
参考文献
Graf
Journal fuer Praktische Chemie (Leipzig), 1933 , vol. <2> 138, p. 244,257
参考文献
Graf
Journal fuer Praktische Chemie (Leipzig), 1933 , vol. <2> 138, p. 244,257
反应条件
sodium cyanoborohydride; acetic acid in water; acetonitrile T=20°C; 18.5 h;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 95 ;
WO 2009/042694 A1
