4-(1,3-二氧代异吲哚啉-2-基)丁醛合成路线 （共 27 条）
反应条件
1: Br2 / CCl4 / Ambient temperature 2: acetone / Ambient temperature View Scheme
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in dichloromethane T=20°C; 0.333333 h; 2: With hydrogen bromide
参考文献
Kowalski, Piotr; Jaskowska, Jolanta
Archiv der Pharmazie, 2012 , vol. 345, # 1 p. 81 - 85
反应条件
1: BF3*Et2O
2: 82 percent / acetone / 0.42 h / Ambient temperature; Irradiation
3: 58 percent / Raney Ni / ethanol / Heating
View Scheme
参考文献
Wada, Masao; Nakai, Hideo; Sato, Yasuhiko; Hatanaka, Yasumaru; Kanaoka, Yuichi
Tetrahedron, 1983 , vol. 39, # 16 p. 2691 - 2698
反应条件
boron trifluoride diethyl etherate in diethyl ether
T=25°C;
参考文献
Wada, Masao; Nakai, Hideo; Sato, Yasuhiko; Hatanaka, Yasumaru; Kanaoka, Yuichi
Tetrahedron, 1983 , vol. 39, # 16 p. 2691 - 2698
反应条件
sodium tris(acetoxy)borohydride in dichloromethane
参考文献
Crawford, Jason B.; Chen, Gang; Gauthier, David; Wilson, Trevor; Carpenter, Bryon; Baird, Ian R.; McEachern, Ernie; Kaller, Alan; Harwig, Curtis; Atsma, Bem; Skerlj, Renato T.; Bridger, Gary J.
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 823 - 830
反应条件
1: potassium carbonate / tetrahydrofuran / 1 h
2: zinc(II) chloride; sodium tetrahydroborate / tetrahydrofuran / 2 h / -20 - -10 °C
View Scheme
参考文献
Crawford, Jason B.; Chen, Gang; Gauthier, David; Wilson, Trevor; Carpenter, Bryon; Baird, Ian R.; McEachern, Ernie; Kaller, Alan; Harwig, Curtis; Atsma, Bem; Skerlj, Renato T.; Bridger, Gary J.
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 823 - 830
反应条件
1: With 1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl-formamide
0.333333 h;
2: With palladium diacetate in N,N-dimethyl-formamide
T=85°C;
参考文献
Hu, Chunmei; Qin, Hua; Cui, Yuxin; Jia, Yanxing
Tetrahedron, 2009 , vol. 65, # 45 p. 9075 - 9080
