(1R)6,6-二甲基联环(3.1.1)庚烷-2-烯-2-乙醇合成路线 （共 13 条）
反应条件
trichloroisocyanuric acid in methanol T=20°C; 4 h;
参考文献
Firouzabadi, Habib; Iranpoor, Nasser; Hazarkhani, Hassan
Synthetic Communications, 2004 , vol. 34, # 19 p. 3623 - 3630
反应条件
sulfated zinc ferrite in toluene T=95°C; 12 h; Reagent/catalystTemperatureConcentrationSolvent;
参考文献
Catalysis Today, , vol. 198, # 1 p. 98 - 105
参考文献
Weissman, Steven A.; Ramachandran, P. Veeraraghavan
Tetrahedron Letters, 1996 , vol. 37, # 22 p. 3791 - 3794
反应条件
zirconium tetrahydroxide T=80°C; Prins reaction; 12 h;
参考文献
Applied Catalysis A: General, , vol. 390, # 1-2 p. 158 - 165
反应条件
1: triethylamine / dichloromethane / 5 - 25 °C 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 5 h / 25 °C / 45004.5 Torr View Scheme
参考文献
PURDUE PHARMA L.P.; TADESSE, Dawit; TAFESSE, Laykea; ZHOU, Xiaoming
Patent: WO2012/85648 A1, 2012 ;
WO 2012/085648 A1
反应条件
1: pyridine 2: 1) K2CO3 / 1) DMF, 2 h, 130 - 140 deg C, 2) 15 h, 120 - 130 deg C 3: hydrazine monohydrate / methanol / 10 h / Heating View Scheme
参考文献
Midland, M. Mark; Kazubski, Aleksander
Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2953 - 2956
反应条件
1: NaH / tetrahydrofuran 2: 1.) LiAlH4, AlBr3, 2.) H2O / 1.) benzene, Et2O, 20 deg C, 4 h, 2.) Et2O, -10 deg C, 0.5 h 3: PPh3, Br2 / chlorobenzene / 4 h / 125 °C 4: 1.) Mg, 2.) O2, 3.) H2O / 1.) Et2O 5: PCC / CH2Cl2 View Scheme
参考文献
Gorobetz, E. V.; Kasatkin, A. N.; Kutchin, A. V.; Tolstikov, G. A.
Russian Chemical Bulletin, 1994 , vol. 43, # 3 p. 466 - 470
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1994 , # 3 p. 506 - 510
反应条件
bei laengerem Kochen oder beim Leiten des Dampfes durch ein auf 350-450grad erhitztes Rohr;
参考文献
Glidden Co.
Patent: US2453110 , 1944 ;
Full Text Show Details
Bain
Journal of the American Chemical Society, 1946 , vol. 68, p. 638,641
Full Text Show Details
Glidden Co.
Patent: US2428352 , 1944 ;
Full Text Show Details
Bain et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4292,4296
反应条件
1: 225 - 240 °C
2: Raney nickel / 73550.8 - 102971 Torr / Hydrogenation
View Scheme
参考文献
Ohloff
Archiv der Pharmazie (Weinheim, Germany), 1954 , vol. 287, p. 272,278
反应条件
sodium hydride in tetrahydrofuran
1 h, room temperature then reflux;
参考文献
Midland, M. Mark; Tramontano, Alfonso; Kazubski, Aleksander; Graham, Richard S.; Tsai, David J. S.; Cardin, Daniel B.
Tetrahedron, 1984 , vol. 40, # 8 p. 1371 - 1380
